本文關鍵詞：補腎促排卵湯聯(lián)合針刺治療腎虛血瘀型未破裂卵泡黃素化綜合征的臨床研究　出處：《南京中醫(yī)藥大學》2017年碩士論文　論文類型：學位論文

  更多相關文章： 未破裂卵泡黃素化綜合征(LUFS) 針刺 補腎促排卵湯 臨床研究

【摘要】：目的:觀察聯(lián)合運用夏桂成教授的補腎促排卵湯加減及針刺治療腎虛血瘀型未破裂卵泡黃素化綜合征(Luteinized Unrupture Follicle Syndrome,LUFS)的臨床療效,通過對比三組患者治療前后外周血激素促黃體生成素(Luteotropic Hormone,LH)、雌二醇(Estradiol,E2)、孕酮(Progesterone,P)水平的差異及基礎體溫的變化情況,探討補腎促排卵湯加減聯(lián)合針刺是否在腎虛血瘀型LUFS的治療中具有優(yōu)勢,提高妊娠率,進一步指導臨床應用。方法:選擇符合本課題納入標準的腎虛血瘀型未破裂黃素化綜合征患者90例,隨機將其分為三組,西藥組(HCG組)、中西藥組(補腎促排卵方+HCG組)、針藥組(針刺+補腎促排卵方+HCG組),所有患者各治療三個月經(jīng)周期。觀察各組患者BBT類型及HPS評分,HCG日各組患者的E2、LH值以及排卵一周后的P值,并從排卵率、妊娠率等方面進行比較。結(jié)果:①中醫(yī)臨床癥候積分:中西藥組及針藥組的治療后平均積分對比治療前均有所降低(P0.05),西藥組的中醫(yī)臨床癥候治療后未獲得明顯的改善(P0.05)。且從治療后下降的差值比較,針藥組顯著優(yōu)于中西藥組(P0.05)。②HPS評分:中西藥組及針藥組的治療后平均積分對比治療前均有所上升(P0.05),西藥組的HPS評分治療后未獲得明顯的改善(P0.05)。且從治療后上升的差值比較,針藥組上升更多(P0.05)。③激素水平:中西藥組及針藥組的治療后E2水平對比治療前均有所提高(P0.05),且針藥組明顯優(yōu)于中西藥組(P0.05)。西藥組的E2水平治療后未獲得明顯的提高(P0.05)。三組患者的LH、P水平治療后均有不同程度的改善(P0.05),且改善程度針藥組中西藥組西藥組(P0.05)。④排卵率、妊娠率:針藥組的排卵率為59.21%,中西藥組為46.91%,西藥組為36.05%,同樣針藥組的妊娠率為63.33%,中西藥組為36.67%,西藥組為13.33%,三組比較有顯著差異性(P0.05)。結(jié)論:針刺聯(lián)合藥物及補腎促排卵湯聯(lián)合HCG的治療方式,相比于單純使用HCG治療能明顯提高患者的排卵率,妊娠率,改善患者的臨床癥狀,且針藥聯(lián)合的治療效果優(yōu)于補腎促排卵湯聯(lián)合HCG。研究結(jié)果表明運用針刺聯(lián)合夏桂成教授的補腎促排卵湯加上HCG治療腎虛血瘀型LUFS的效果相比傳統(tǒng)單一的藥物療法具有一定的臨床優(yōu)勢。
[Abstract]:Objective: to observe the treatment of unruptured follicular luteinization syndrome of kidney deficiency and blood stasis type by combined use of Professor Xia Guicheng's tonifying kidney and promoting ovulation decoction and acupuncture. Luteinized Unrupture Follicle Syndrome. The clinical effects of LUFS were compared before and after treatment with luteotropin luteotropin (LH). The difference of estradiol Estradiolus E _ (2) and progesterone (P) and the change of basal body temperature. To explore whether the combination of tonifying kidney promoting ovulation decoction and acupuncture has advantages in the treatment of kidney deficiency and blood stasis type LUFS and improve the pregnancy rate. Methods: 90 patients with unruptured luteinization syndrome of kidney deficiency and blood stasis syndrome were selected and randomly divided into three groups: Western medicine group (HCG group). Chinese and western medicine group (tonifying kidney and promoting ovulation prescription HCG group), acupuncture group (acupuncture kidney promoting ovulation prescription HCG group), all patients were treated for three menstrual cycles. BBT type and HPS score were observed in each group. On the day of HCG, the value of E2T LH and the P value after one week of ovulation, and the rate of ovulation. Results: the clinical symptom score of traditional Chinese medicine: the average score of TCM group and acupuncture group were decreased before treatment (P 0.05). The clinical symptoms of traditional Chinese medicine in the western medicine group were not significantly improved after treatment, and the difference value decreased after treatment. The average score of acupuncture and medicine group was significantly better than that of traditional Chinese medicine group and western medicine group. The average score of acupuncture and medicine group was higher than that of traditional Chinese medicine group and acupuncture medicine group before treatment (P 0.05). The HPS score of the western medicine group was not significantly improved after treatment, and the difference between the two groups was higher than that of the control group (P 0.05). The level of estradiol in the acupuncture and medicine group increased more than that in the western medicine group and the acupuncture and medicine group. The level of E _ 2 in the Chinese medicine group and the acupuncture medicine group after treatment was increased before treatment (P 0.05). The level of E2 in the western medicine group was not significantly improved after treatment. The LH of the three groups was significantly higher than that of the western medicine group. The P level was improved in different degree after treatment, and the ovulation rate was 59.21% in the acupuncture and medicine group, the western medicine group and the western medicine group. The pregnancy rate was 59.21% in the acupuncture and medicine group. The pregnancy rate was 63.33 in the Chinese medicine group, 36.67 in the western medicine group and 13.33% in the western medicine group. Conclusion: acupuncture combined with drugs and kidney promoting ovulation decoction combined with HCG can significantly improve the ovulation rate compared with the treatment of HCG alone. Pregnancy rate, improve the clinical symptoms of patients. The therapeutic effect of acupuncture combined with medicine was better than that of tonifying kidney promoting ovulation decoction combined with HCG.Results showed that acupuncture combined with Professor Xia Guicheng's Bushen promoting ovulation decoction plus HCG in the treatment of LUFS with kidney deficiency and blood stasis was more effective than that of traditional Chinese medicine. Single drug therapy has certain clinical advantages.
【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R271.9

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