本文關(guān)鍵詞：熱毒寧注射液抗甲型H1N1流感病毒作用機(jī)制研究，由筆耕文化傳播整理發(fā)布。

熱毒寧注射液抗甲型H1N1流感病毒作用機(jī)制研究

Mechanism of Reduning Injection against influenza A/H1N1 virus

[1] [2] [3] [4] [5] [6]

WANG Zhen-zhong1＇ 2 BAO Lin-lin3, SUN Lan1＇ 2, BI Yu-an1＇ 2, ZHOU Jurl1＇ 2, XIAO Wei1＇ 2 1. Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China 2. State Key Laborato

[1]江蘇康緣藥業(yè)股份有限公司,江蘇連云港222001; [2]中藥制藥過(guò)程新技術(shù)國(guó)家重點(diǎn)實(shí)驗(yàn)室,江蘇連云港222001; [3]中國(guó)醫(yī)學(xué)科學(xué)院醫(yī)學(xué)實(shí)驗(yàn)動(dòng)物研究所,北京100021

文章摘要：目的研究熱毒寧注射液體內(nèi)抗甲型H1N1流感病毒的作用及其機(jī)制。方法采用甲型H1N1流感病毒滴鼻感染BALB／c小鼠制備肺炎模型，，觀察熱毒寧注射液對(duì)甲型H1N1流感病毒感染小鼠平均存活時(shí)間、存活率、肺指數(shù)、病毒載量及細(xì)胞因子的影響。結(jié)果與模型組比較，熱毒寧注射液顯著提高病毒感染小鼠的存活率、延長(zhǎng)小鼠平均存活時(shí)間（P〈0．05、0．01）；顯著降低病毒感染小鼠肺指數(shù)、肺組織病毒載量（P〈0．05、0．01）；提高肺組織丫干擾素（IFN-γ）水平，降低白細(xì)胞介素-6（IL-6）、腫瘤壞死因子α（TNF-α）水平。結(jié)論熱毒寧注射液對(duì)甲型H1N1流感病毒感染小鼠具有一定的保護(hù)作用，其作用機(jī)制可能與提高IFN-γ，水平，降低IL-6、TNF-α水平有關(guān)。

Abstr：Objective To investigate the effect of Reduning Injection （RI） on the resistance to influenzaA/H1N1 vires and its mechanism. Methods The pneumonic model of BALB/c mice was established by influenza A/H1N1 virus, and the average survival period, survival rate, lung index, viral load, and cytokine level of mice infected by influenza A/H1N1 virus were observed. Results Compared with the model group, RI significantly increased the survival rate and prolonged the average survival period of mice infected by influenza A/H1N1 virus （P 〈 0.05, 0.01）. RI significantly reduced the lung index, viral load, contents of IL-6 and TNF-α, while increased the content of IFN-γ （P 〈 0.05, 0.01）. Conclusion RI has the certain protective effect on mice infected by influenza A/H1N1 virus. Its mechanism may be related to the improvement of the content oflFN-y and the decrease of the contents of IL-6 and TNF-α.

文章關(guān)鍵詞：

Keyword：:Reduning Injection influenza A/H1N1 virus viral load lung index cytokines

課題項(xiàng)目：現(xiàn)代中藥創(chuàng)新集群與數(shù)字制藥技術(shù)平臺(tái)（2013ZX09402203）

  本文關(guān)鍵詞：熱毒寧注射液抗甲型H1N1流感病毒作用機(jī)制研究，由筆耕文化傳播整理發(fā)布。