發(fā)布時間：2019-02-16 07:28

【摘要】：目的　研究槍擊噪音對大鼠液體食物胃腸傳輸?shù)挠绊?,并通過測定大鼠血漿胃腸激素濃度的變化探討槍擊噪音致胃腸傳輸功能紊亂發(fā)生的機(jī)制。方法　 32只SD大鼠隨機(jī)分組 ,以模擬 5 6式?jīng)_鋒槍射擊時產(chǎn)生的噪音為施加因素 ,分別給予不同強(qiáng)度的噪音刺激 ,采用炭粉推進(jìn)法觀察不同強(qiáng)度的聲刺激對大鼠液體食物胃腸傳輸?shù)挠绊?,通過放射免疫法測定血漿胃腸激素濃度 ,包括血漿胃動素(MLT)、生長抑素 (SS)、P物質(zhì) (SP)、血管活性腸肽(VIP)。結(jié)果　當(dāng)槍擊噪音強(qiáng)度在 80dB以下時 ,大鼠胃腸傳輸液體食物速度為輕度抑制 ,與對照組比較差異無統(tǒng)計學(xué)意義 (P 0 0 5 ) ;噪音強(qiáng)度達(dá) 80dB時 ,血漿SS、SP、VIP濃度均較對照組升高 ,差異有統(tǒng)計學(xué)意義 (P 0 0 5或P 0 0 1) ;當(dāng)槍擊噪音達(dá)到 12 0dB時 ,大鼠胃腸傳輸液體食物速度較對照組明顯加快 (P 0 0 5 ) ,同時血漿MLT、SS、SP的濃度也發(fā)生了明顯的變化 (P 0 0 1)。結(jié)論　當(dāng)槍擊噪音在一定強(qiáng)度范圍內(nèi)時 ,大鼠血漿胃腸激素濃度已發(fā)生改變 ,但其胃腸對液體食物的傳輸功能仍保持在相對正常的范圍 ;當(dāng)槍擊噪音超過一定強(qiáng)度時 ,大鼠血漿胃腸激素濃度發(fā)生了明顯的變化 ,其胃腸對液體食物的傳輸功能發(fā)生紊亂。
[Abstract]:Objective to study the effect of gunshot noise on gastrointestinal transport of liquid food in rats and to explore the mechanism of gastrointestinal transport dysfunction induced by gunshot noise by measuring the concentration of gastrointestinal hormones in plasma of rats. Methods Thirty-two SD rats were randomly divided into two groups. The noise produced by simulating 56 type submachine gun was used as the applied factor, and the noise stimulation of different intensity was given respectively. The effects of different intensities of acoustic stimulation on gastrointestinal transport of liquid food in rats were observed by carbon powder propulsion method. Plasma gastrointestinal hormones, including plasma motilin (MLT), somatostatin (SS), were measured by radioimmunoassay. Substance P (SP), vasoactive intestinal peptide (VIP). Results when the noise intensity of gunshot was below 80dB, the food velocity of gastrointestinal liquid was slightly inhibited in rats, and there was no significant difference compared with the control group (P 0.05). When the noise intensity reached 80dB, the plasma SS,SP,VIP concentration was significantly higher than that in the control group (P 0 05 or P 0 01). When the gunshot noise reached 12 0dB, the food delivery rate of gastrointestinal fluid in rats was significantly faster than that in the control group (P 0.05), and the concentration of plasma MLT,SS,SP also changed significantly (P 0.01). Conclusion when the shot noise is within a certain range of intensity, the concentration of gastrointestinal hormones in plasma of rats has been changed, but the function of gastrointestinal transport to liquid food is still in a relatively normal range. When the gunshot noise exceeded a certain intensity, the concentration of gastrointestinal hormones in plasma of rats was obviously changed, and the gastrointestinal transport function of liquid food was disturbed.
【作者單位】： 第四軍醫(yī)大學(xué)唐都醫(yī)院 第四軍醫(yī)大學(xué)唐都醫(yī)院 第四軍醫(yī)大學(xué)唐都醫(yī)院 第四軍醫(yī)大學(xué)唐都醫(yī)院 第四軍醫(yī)大學(xué)唐都醫(yī)院 第四軍醫(yī)大學(xué)唐都醫(yī)院
【分類號】：R82

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