發(fā)布時(shí)間：2018-11-03 09:38

【摘要】：目的　探討高原高寒環(huán)境下肢體火器傷后全身應(yīng)激反應(yīng)的特點(diǎn)。方法　將2 4頭豬隨機(jī)分為高原戰(zhàn)時(shí)致傷組(GZ)、高原平時(shí)致傷組(GP)和平原平時(shí)致傷組(PP) ,每組8只、復(fù)制肢體火器傷模型。分別于傷前、傷后10、3 0min、2、6、12、2 4、48、72、12 0h采靜脈血測定血漿氫化可的松和腎上腺素。結(jié)果　3組豬血漿氫化可的松含量均于傷后10min明顯升高、3 0min達(dá)高峰,高原戰(zhàn)時(shí)致傷組血漿氫化可的松含量增高幅度最大,約為高原平時(shí)致傷組的2倍、平原平時(shí)致傷組的4倍;高原戰(zhàn)時(shí)致傷組血漿腎上腺素含量于傷后10min明顯升高并達(dá)高峰,約為傷前的40倍、高原平時(shí)致傷組的1 5倍、平原平時(shí)致傷組的1 8倍。平原平時(shí)致傷組血漿氫化可的松和腎上腺素含量均在傷后48h恢復(fù)到正常水平,高原平時(shí)致傷組在傷后72h時(shí)恢復(fù)到正常水平,高原戰(zhàn)時(shí)致傷組在傷前血漿氫化可的松和腎上腺素含量就大大高于其它兩組,一直到傷后12 0h仍然保持在較高水平。結(jié)論　高原高寒環(huán)境戰(zhàn)時(shí)豬肢體槍彈傷后全身應(yīng)激反應(yīng)明顯重于高原平時(shí)致傷組和平原平時(shí)致傷組,而且持續(xù)的時(shí)間長。
[Abstract]:Objective to investigate the characteristics of systemic stress response after firearm injury in high altitude and cold environment. Methods Twenty-four pigs were randomly divided into two groups: (GZ), group (n = 8), (GP) group (n = 8) and plain group (n = 8). Plasma hydrocortisone and epinephrine were measured in venous blood samples for 120 hours before and 10 30 minutes after injury. Results the levels of plasma hydrocortisone in the three groups were significantly higher than those in the post-injury group, and reached the peak at 3 0min. The plasma hydrocortisone content in the high altitude wartime injury group was the highest, which was about twice as high as that in the plateau peacetime injury group. The level of injury in plain was 4 times as high as that in normal time. The plasma epinephrine content in the high altitude wartime injury group was significantly higher than that before the injury and reached the peak, about 40 times as high as before, 1.5 times as much as the plateau peacetime injury group, and 18 times as high as the plain peacetime injury group. The plasma levels of hydrocortisone and epinephrine returned to normal level in plain normal injury group at 48 h after injury, and returned to normal level at 72 h after injury in plateau injury group. The plasma levels of hydrocortisone and epinephrine in the high altitude wartime group were significantly higher than those in the other two groups, and remained at a relatively high level until 120 hours after injury. Conclusion the whole body stress response after gunshot wound of pig limbs in high altitude and cold environment was significantly more serious than that in plateau injury group and plain injury group, and lasted for a long time.
【作者單位】： 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所第二研究室 創(chuàng)傷、燒傷與復(fù)合傷國家重點(diǎn)實(shí)驗(yàn)室 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所第二研究室 創(chuàng)傷、燒傷與復(fù)合傷國家重點(diǎn)實(shí)驗(yàn)室 西藏軍區(qū)總醫(yī)院骨科 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所第二研究室 創(chuàng)傷、燒傷與復(fù)合傷國家重點(diǎn)實(shí)驗(yàn)室 西藏軍區(qū)總醫(yī)院骨科 第三軍醫(yī)大學(xué)大坪醫(yī)院野戰(zhàn)外科研究所第二研究室 創(chuàng)傷、燒傷與復(fù)合傷國家重點(diǎn)實(shí)驗(yàn)室 西藏軍區(qū)總醫(yī)院骨科 西藏軍區(qū)總醫(yī)院骨科 西藏軍區(qū)總醫(yī)院骨科
【基金】：全軍“十五”指令性課題 ( 0 1L0 0 8)~~
【分類號(hào)】：R826.2

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 劉杰;創(chuàng)傷后應(yīng)激反應(yīng)中熱休克蛋白的作用(文獻(xiàn)綜述)[J];國外醫(yī)學(xué).外科學(xué)分冊(cè);2000年01期

2 蔣小華,李寧,李元新,劉放南,譚力,黎介壽;手術(shù)創(chuàng)傷應(yīng)激下腸黏膜通透性的改變及腸內(nèi)腸外營養(yǎng)作用的比較[J];中華胃腸外科雜志;2001年04期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 蔣小華,李寧,朱維銘,黎介壽;胃癌術(shù)后早期腸內(nèi)免疫營養(yǎng)的作用[J];腸外與腸內(nèi)營養(yǎng);2005年02期

2 李忠;巴哈提;李軍;王麗;尹勇;王榮朝;王海濤;王R，

本文編號(hào)：2307410