【摘要】：微重力狀態(tài)下骨量丟失不同于老年性骨質(zhì)疏松,是一種局部力學(xué)信號轉(zhuǎn)導(dǎo)起主導(dǎo)作用、并受多層次調(diào)節(jié)的復(fù)雜變化過程,是一種特殊的廢用性骨質(zhì)疏松和繼發(fā)性骨質(zhì)疏松。長期的微重力環(huán)境,骨礦鹽的持續(xù)丟失是航天飛行中人類所面臨的嚴(yán)重生理反應(yīng)之一,也是妨礙人類長期太空停留和探索外星球的主要障礙之一。目前微重力環(huán)境下骨量丟失的對抗措施主要有:物理對抗、營養(yǎng)、藥物、細(xì)胞因子與基因治療。航天飛行中,阻力鍛煉、振動、人工重力等物理對抗措施的研究較為成熟;營養(yǎng)措施中著重闡述維生素、礦物質(zhì)、蛋白質(zhì)、Ω-3脂肪酸對骨代謝的作用,各種營養(yǎng)物質(zhì)的具體攝入量仍有待規(guī)范;藥物措施中雙膦酸鹽的使用基本得到廣泛認(rèn)可,其他藥物的應(yīng)用仍需要繼續(xù)人體探索;細(xì)胞因子與基因的研究目前仍限于應(yīng)用細(xì)胞進(jìn)行研究。高級阻力訓(xùn)練系統(tǒng)(ARED)聯(lián)合營養(yǎng)(部分聯(lián)合雙膦酸鹽)是目前公認(rèn)有效的對抗航天飛行中骨量丟失的措施。本文將詳細(xì)闡述以上各個(gè)方面國內(nèi)外的進(jìn)展及爭議,以及探討未來微重力狀態(tài)下骨量丟失的對抗措施的發(fā)展方向。
[Abstract]:Bone loss in microgravity is different from senile osteoporosis. It is a kind of local mechanical signal transduction leading role, and is regulated by multilevel complex process. It is a special kind of disuse osteoporosis and secondary osteoporosis. Long term microgravity environment, the continuous loss of bone mineral salt is faced by human beings in space flight. One of the major physiological responses of human beings is one of the major obstacles to the long-term space stay and exploration of the planet. The main countermeasures for the loss of bone mass in the environment of microgravity are physical countermeasures, nutrition, drugs, cytokine and gene therapy. Research on physical countermeasures such as resistance exercise, vibration and artificial gravity in space flight The effects of vitamins, minerals, proteins, Omega -3 fatty acids on bone metabolism and the specific intake of various nutrients are still to be standardized; the use of bisphosphonates in drug measures is widely accepted, and the application of other drugs still needs to continue to explore the human body; the study of cytokines and genes The advanced resistance training system (ARED) combined nutrition (partially combined bisphosphonates) is currently recognized as an effective measure to combat the loss of bone mass in space flight. This article will elaborate on the progress and disputes at home and abroad in the above aspects in order to explore the resistance of bone mass loss in the future microgravity state. The direction of the development of the measures.
【作者單位】： 戰(zhàn)略支援部隊(duì)航天系統(tǒng)部航天城門診部;
【分類號】：R85

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1 楊月蓮;劉宏;蔡德鴻;;失重性骨量丟失治療對策[J];中國骨質(zhì)疏松雜志;2006年05期

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本文編號：2142316