本文選題：模擬失重 + 大鼠��； 參考：《航天醫(yī)學(xué)與醫(yī)學(xué)工程》2014年06期

【摘要】：目的研究內(nèi)關(guān)穴位刺激對抗模擬失重大鼠心功能變化的作用,探索對抗失重環(huán)境下生理學(xué)變化的新措施。方法采用尾部懸吊模擬失重生理效應(yīng)。大鼠隨機(jī)分成3組:對照組(Con),尾吊30天組(TS),尾吊30天加內(nèi)關(guān)穴位隔日刺激組(TS+neiguan),每組10只大鼠。結(jié)果與Con組比,TS組和TS+neiguan大鼠空腹體重明顯下降(P0.05)。超聲心動(dòng)圖指標(biāo)TS組室間隔舒張末期厚度(IVSd)、室間隔收縮末期厚度(IVSs)、左室短軸縮短率(FS)、左室舒張末期后壁厚度(LVPWd)下降(P0.05);左室舒張末期內(nèi)徑(LVDd)和左室射血分?jǐn)?shù)(EF)顯著下降(P0.01);心率(HR)顯著升高。穴位刺激組盡管所有指標(biāo)有類似于TS組的變化趨勢,但與Con組相比,差別無統(tǒng)計(jì)學(xué)意義,且TS+neiguan組LVDd明顯高于TS組(P0.01)。去甲腎上腺素(NE)和腎上腺素(EPI)含量TS大鼠均明顯高于對照組(P0.01)和TS+neiguan組(P0.05);TS+neiguan與Con組比無明顯差別。血清血管緊張素Ⅱ(AngⅡ)和皮質(zhì)酮(CORT)含量各組間無差別。醛固酮(ALD)含量TS組和TS+neiguan組明顯高于Con組(P0.05,P0.01)。結(jié)論模擬失重主要引起左心室功能降低和結(jié)構(gòu)變化,心血管調(diào)節(jié)功能變化,內(nèi)關(guān)穴位刺激能較好對抗這些不利影響,在對抗失重生理變化方面可能有較好應(yīng)用前景。
[Abstract]:Objective to study the effects of Neiguan acupoint stimulation on the changes of cardiac function in simulated weightlessness rats, and to explore new measures for antagonizing physiological changes in weightlessness. Methods the effects of weightlessness were simulated by tail suspension. Rats were randomly divided into three groups: control group (Con), tail suspension group (TS) for 30 days, tail suspension group for 30 days and Neiguan acupoint stimulation group (TS neiguan),) for each group of 10 rats. Results compared with Con group, the fasting body weight of TS and TS neiguan rats decreased significantly (P0.05). Echocardiographic indicators of left ventricular septal end diastolic thickness (IVSd), interventricular septal end systolic thickness (IVSs), left ventricular shortening rate (FS), left ventricular posterior diastolic wall thickness (LVPWd), left ventricular end-diastolic diameter (LVDd) and left ventricular ejection fraction (EF) were significantly decreased in TS group (P0.05). The heart rate (HR) increased significantly. Although all the indexes of acupoint stimulation group were similar to those of TS group, there was no significant difference compared with Con group, and LVDd in TS neiguan group was significantly higher than that in TS group (P0.01). The contents of norepinephrine (NE) and epinephrine (EPI) in TS rats were significantly higher than those in control group (P0.01) and TS neiguan group (P0.05). There was no difference in serum angiotensin 鈪，

本文編號：2109927