本文選題：失重模擬 + 臥床實(shí)驗(yàn)��； 參考：《航天醫(yī)學(xué)與醫(yī)學(xué)工程》2004年06期

【摘要】：目的研究中藥復(fù)方對臥床模擬失重骨超聲速率及骨代謝的影響。方法健康男性 1 6人、- 6°頭低位臥床 3周模擬失重 ,觀察中藥復(fù)方對人體脛骨超聲速率 (speedofsound ,SOS)、血鈣 (Ca)、血磷 (P)、血清堿性磷酸酶同工酶 (ALP)、生長激素 (GH)、甲狀旁腺激素 (PTH)、骨鈣素 (BGP)、腎上腺皮質(zhì)激素(ACTH)等指標(biāo)的作用。結(jié)果與臥床前比較 ,臥床第 7、1 4、2 1天及起床后第 6天脛骨超聲速率 (SOS)均顯著降低 ,P 0 .0 1或P 0 .0 5 ,中藥組比對照組脛骨超聲速率增高 ,但無顯著差異 ;中藥組臥床第1 8天及起床后第 5天血磷均顯著升高 ;中藥組臥床第 1 8天血清堿性磷酸酶同功酶升高 ,與對照組相比差異顯著 ,P 0 .0 1 ;中藥組骨鈣素呈先升后降的趨勢 ,即臥床第 1 8天時(shí)骨鈣素較臥床前升高 ,起床后第 5天骨鈣素較臥床第 1 8天降低 ,經(jīng)統(tǒng)計(jì)學(xué)處理有顯著差異 ,P 0 .0 1或P 0 .0 5 ;中藥組臥床第 1 8天甲狀旁腺激素顯著降低 ,與臥床前比較 ,P 0 .0 5 ;腎上腺皮質(zhì)激素兩組的變化趨勢相同 ,在起床后第5天顯著增高 ,與臥床前及臥床第 1 8天比較差異顯著 ,P 0 .0 1或P 0 .0 5。結(jié)論中藥方可從整體上對抗骨丟失 ,促進(jìn)骨的正常代謝活動(dòng) ,對模擬失重骨丟失有保護(hù)作用。
[Abstract]:Objective to study the effect of traditional Chinese medicine (TCM) on ultrasonic velocity and bone metabolism of simulated weightlessness in bed. Methods 16 healthy men were left in bed with 6 擄head position for 3 weeks simulated weightlessness. To observe the effects of traditional Chinese medicine (TCM) on the indexes of tibia ultrasonic rate speedofsound SOS, serum calcium, serum phosphatase, serum alkaline phosphatase isoenzyme (ALP), growth hormone (GH), parathyroid hormone (PTH), osteocalcin (BGP), adrenal cortical hormone (ACTH), and so on. Results compared with those before bed rest, the ultrasound rate of tibia on day 7 and day 6 after bed rest decreased significantly (P 0. 01 or P 0. 05). The ultrasound rate of tibia in the Chinese medicine group was higher than that in the control group, but there was no significant difference between the Chinese medicine group and the control group. Serum phosphorus in the Chinese medicine group increased significantly on the 18th day after bed rest and on the fifth day after getting up, and the serum alkaline phosphatase isoenzyme increased on the 18th day after bed rest in the traditional Chinese medicine group, which was significantly higher than that in the control group (P < 0.01). In the Chinese medicine group, the osteocalcin increased at the 18th day after bed rest, and decreased on the fifth day after getting up, and then decreased on the fifth day after getting up. After statistical analysis, there were significant differences in P 0. 01 or P 0. 05; parathyroid hormone in the Chinese medicine group decreased significantly on the 18th day after bed rest, compared with that before bed rest; the change trend of adrenocortical hormone in the two groups was the same. On the 5th day after getting up, the difference was significant (P 0. 01 or P 0. 05) as compared with that before bed rest and 18 days after bed rest. Conclusion Chinese herbal medicine can prevent bone loss, promote normal metabolism of bone, and protect simulated weightlessness bone loss.
【作者單位】： 中國醫(yī)學(xué)科學(xué)院協(xié)和醫(yī)科大學(xué)藥用植物研究所 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所 航天醫(yī)學(xué)工程研究所
【基金】：中國載人航天工程基金資助
【分類號】：R852.22;R856.2

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