本文關(guān)鍵詞：高分子藥物學(xué)的研究進(jìn)展與期盼，由筆耕文化傳播整理發(fā)布。

高分子藥物學(xué)的研究進(jìn)展與期盼

THE PROGRESS AND EXPECTATION OF POLYMER PHARMACY

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Xiu-li Hu, Zhi-gang Xie, Yu-bin Huang, Xia-bin Jing （State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry Chinese Academy of Scienc

中國(guó)科學(xué)院長(zhǎng)春應(yīng)用化學(xué)研究所高分子物理和化學(xué)國(guó)家重點(diǎn)實(shí)驗(yàn)室,長(zhǎng)春130022

文章摘要：自從20世紀(jì)70年代提出高分子前藥的概念以來(lái)，伴隨著納米技術(shù)的發(fā)展，“高分子藥物學(xué)”作為高分子科學(xué)和材料學(xué)、納米科學(xué)、藥物學(xué)、臨床醫(yī)學(xué)、分析科學(xué)的交叉學(xué)科，正在悄然形成．本文綜述了近年高分子藥物在藥物化學(xué)、制劑學(xué)、藥效學(xué)等方面所取得的進(jìn)展，概述了高分子藥物的藥理學(xué)和藥代動(dòng)力學(xué)與小分子藥物的區(qū)別與聯(lián)系，指出了高分子藥物藥效學(xué)、藥理學(xué)和藥代動(dòng)力學(xué)研究中的難題和瓶頸，特別是高分子藥物可能存在的“三種狀態(tài)”及從“納米顆粒藥”到“單個(gè)高分子藥”再到“小分子藥”的轉(zhuǎn)變，分析了高分子藥輸送過(guò)程中存在的多重屏障如毛細(xì)血管壁、細(xì)胞外基質(zhì)和細(xì)胞壁等，闡述了高分子藥物的“生理靶向”和“EPR”效應(yīng)的競(jìng)爭(zhēng)，指出了高分子藥在靶向輸送和逆轉(zhuǎn)耐藥方面的優(yōu)勢(shì)，強(qiáng)調(diào)了發(fā)展相關(guān)分析方法的必要性，，期盼高分子科學(xué)家與藥物學(xué)家進(jìn)行真誠(chéng)有效的合作，大力促進(jìn)我國(guó)高分子藥物學(xué)和高分子藥物產(chǎn)業(yè)的創(chuàng)新和發(fā)展．

Abstr：Since the ＂ polymer prodrug＂ concept was first proposed in 1970s,＂polymer pharmacy＂, as the interdiscipline of polymer science, material science, nano-science, pharmacy, clinical medicine and analysis science, has been quietly born along with the development of nanotechnology. In this paper, an overview of the progress of polymer drugs in pharmacochemistry, pharmaceutics, and pharmacodynamics is provided; the connection and distinction between polymer drugs and small molecule drugs in pharmacology and pharmacokinetics are outlined; the bottleneck tissues in pharmacodynamics and pharmacokinetics of polymer drugs are pointed out, especially the ＂three states＂ of polymer drugs and the transformation of the ＂ nano- particle drug＂ through ＂ macromolecular drug＂ to ＂ small molecular drug＂; the multiple obstacles on the pathway of polymer drugs such as capillary vessel wall, extracellular substance, cellular wall, etc. , are analyzed; the competition between the ＂physiological targeting＂ of human organs and the ＂ EPR effect＂ of cancerous tissues is elucidated ; the possible contribution and merits of polymer drugs in drug targeting delivery and in reversion of drug resistance are pointed out; the necessity of developing the related analytical methods is emphasized; and an urgent expectation is expressed that scientists and experts working in polymer science and in pharmacology cooperate with each other sincerely and effectively to promote the innovation and development in polymer pharmacy and polymer drug industry in our country.

文章關(guān)鍵詞：

Keyword：:Polymer drugs, Polymer prodrug, Polymer pharmacy, Polymer pharmacology, Polymer pharmacokinetics, Polymer pharmacodynamics

課題項(xiàng)目：國(guó)家自然科學(xué)基金項(xiàng)目（基金號(hào)21004062,51103148）和國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃,項(xiàng)目號(hào)2009CB930102）.

作者信息：會(huì)員可見(jiàn)

  本文關(guān)鍵詞：高分子藥物學(xué)的研究進(jìn)展與期盼，由筆耕文化傳播整理發(fā)布。