麻醉大鼠冰水灌耳交感神經(jīng)響應(yīng)在心血管調(diào)節(jié)中的作用
發(fā)布時(shí)間:2018-05-23 14:29
本文選題:交感神經(jīng)響應(yīng) + 心血管調(diào)節(jié) ; 參考:《航天醫(yī)學(xué)與醫(yī)學(xué)工程》2006年06期
【摘要】:目的研究冰水灌耳刺激引起的交感神經(jīng)響應(yīng)、心率以及血壓調(diào)節(jié)之間的內(nèi)在聯(lián)系,探討前庭刺激在心血管調(diào)節(jié)中的作用。方法記錄正常麻醉(CON)大鼠(n=5)、壓力反射去除(SAD)大鼠(n=5)和迷路毀損(VD)大鼠(n=5)在冰水灌耳時(shí)內(nèi)臟大神經(jīng)傳出放電及血壓和心率的變化。結(jié)果正常麻醉大鼠灌耳后,血壓、心率降低,內(nèi)臟大神經(jīng)反應(yīng)由增強(qiáng)到減弱。壓力反射去除大鼠灌耳后內(nèi)臟大神經(jīng)活動(dòng)顯著高于迷路毀損大鼠,且兩組動(dòng)物血壓呈相反方向變化。內(nèi)臟大神經(jīng)放電與呼吸的耦合形式受到灌耳刺激的影響。結(jié)論半規(guī)管輸入至少參與了血壓的短時(shí)調(diào)節(jié)機(jī)制,其作用途徑可能涉及呼吸運(yùn)動(dòng)的調(diào)節(jié)機(jī)制,在血壓調(diào)節(jié)中壓力反射和前庭輸入兩者作用不同,在
[Abstract]:Objective to study the relationship among sympathetic response, heart rate and blood pressure regulation induced by ice water perfusion, and to explore the role of vestibular stimulation in cardiovascular regulation. Methods the efferent discharge of splanchnic great nerve and the changes of blood pressure and heart rate were recorded in normal anaesthetized conic rats, baroreflex (SAD) rats and labyrinth (VD5) rats. Results the blood pressure and heart rate of normal anesthetized rats decreased, and the response of splanchnic great nerve increased to weaken. The splanchnic great nerve activity of the rats with baroreflex was significantly higher than that of the rats with labyrinth, and the blood pressure of the two groups was changed in the opposite direction. The coupling form of splanchnic great nerve discharge and respiration is affected by ear stimulation. Conclusion semicircular canal infusion is involved in at least the short-term regulation of blood pressure, and its mechanism may involve in the regulation of respiratory motility. In blood pressure regulation, baroreflex and vestibular infusion play different roles.
【作者單位】: 中國(guó)航天員科研訓(xùn)練中心 中國(guó)航天員科研訓(xùn)練中心 中國(guó)航天員科研訓(xùn)練中心 中國(guó)航天員科研訓(xùn)練中心 中國(guó)航天員科研訓(xùn)練中心 中國(guó)航天員科研訓(xùn)練中心
【基金】:總裝備部試驗(yàn)技術(shù)重點(diǎn)課題(01101307)
【分類(lèi)號(hào)】:R85
【相似文獻(xiàn)】
相關(guān)期刊論文 前2條
1 王林杰;董衛(wèi)軍;張丹;趙琦;仝飛舟;曹毅;;麻醉大鼠冰水灌耳交感神經(jīng)響應(yīng)在心血管調(diào)節(jié)中的作用[J];航天醫(yī)學(xué)與醫(yī)學(xué)工程;2006年06期
2 王林杰;董衛(wèi)軍;張丹;趙琦;仝飛舟;曹毅;;麻醉大鼠冰水灌耳交感神經(jīng)響應(yīng)在心血管調(diào)節(jié)中的作用[J];航天醫(yī)學(xué)與醫(yī)學(xué)工程;2006年06期
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