本文關(guān)鍵詞：傳統(tǒng)藥物對西藥藥代動力學(xué)影響的研究與探索，由筆耕文化傳播整理發(fā)布。

傳統(tǒng)藥物對西藥藥代動力學(xué)影響的研究與探索

An overview of effects of traditional medicine on pharmacokinetics of western medicine

[1] [2] [3]

ZHEN Ya-qin, KONG De-zhi, REN Lei-ming （Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang 050017, China ）

河北醫(yī)科大學(xué)中西醫(yī)結(jié)合研究所,河北石家莊050017

文章摘要：近20年來草藥（或稱植物藥、傳統(tǒng)藥）的使用再次盛行，據(jù)調(diào)查以草藥作為補(bǔ)充和替代藥物的人群占世界人口的70％，近10年的數(shù)據(jù)顯示，加拿大、澳大利亞以及歐洲的草藥消耗量以指數(shù)形式增長。特別是草藥與西藥同時服用己成為一種趨勢，，草藥與西藥聯(lián)合應(yīng)用是一個需要引起高度重視的問題，國際上已有大量文獻(xiàn)、臨床報(bào)告、動物實(shí)驗(yàn)對草藥-西藥相互作用進(jìn)行了廣泛的研究，臨床上對草藥-西藥相互作用的問題也日益關(guān)注。本文綜述了臨床上草藥與西藥聯(lián)合應(yīng)用時所產(chǎn)生的相互作用，及其對患者病情及治療影響的研究。研究內(nèi)容包括草藥-西藥相互作用的臨床表現(xiàn)、循證醫(yī)學(xué)研究和證據(jù)等級標(biāo)準(zhǔn)的建立；在作用機(jī)制方面包括藥物代謝酶的誘導(dǎo)與抑制、轉(zhuǎn)運(yùn)體的誘導(dǎo)與抑制、胃腸道功能的改變、腎臟清除藥物能力的改變等。本文還介紹了國內(nèi)當(dāng)前中藥-西藥聯(lián)合用藥的現(xiàn)狀和存在的問題。

Abstr：Traditional medicine （herb medicine） began to prevail again over last two decades, and it is about 70% of the world population taking herb medicine as supplement or alternative medicine according to a recent survey. The consumption of herb medicine increased exponentially in Canada, Australia and Europe during last 10 years. Since concomitant administration of herbal and western medicine has become a trend, it requires paying close attention to the problem. Herb-drug interactions have been extensively investigated worldwide, and there is an increasing concern about the clinical herb-drug interaction. In this review we introduced the current progress in the herb-drug interactions including evidence-based clinical studies and establishment of levels of evidence for herb-drug interaction; and in the related mechanisms including the induction and inhibition of metabolic enzymes, inhibition and induction of transport and efflux proteins, alteration of gastrointestinal functions, and alteration in renal elimination. We also analyzed both the achievements and the challenges faced in the concomitant administration of traditional Chinese medicine and western medicine.

文章關(guān)鍵詞：

Keyword：:herbal medicine concomitant administration herb-drug interaction mechanisms traditionalChinese medicine

課題項(xiàng)目：國家重點(diǎn)基礎(chǔ)研究發(fā)展計(jì)劃（973計(jì)劃）資助項(xiàng)目（2012CB518601）;國家科技部“重大新藥創(chuàng)制”科技重大專項(xiàng)資助項(xiàng)目（2011ZX09102-011-04）.

作者信息：會員可見

  本文關(guān)鍵詞：傳統(tǒng)藥物對西藥藥代動力學(xué)影響的研究與探索，由筆耕文化傳播整理發(fā)布。