本文選題：加速度　切入點(diǎn)：大鼠　出處：《軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào)》2005年06期 　論文類型：期刊論文

【摘要】：目的:建立持續(xù)性高正加速度(+G z)重復(fù)作用導(dǎo)致大鼠損傷的自然修復(fù)模型。方法:雄性W istar大鼠108只隨機(jī)分成9組,每組12只。A組為空白對(duì)照;B組地面固定5 m in;C組固定于離心機(jī)轉(zhuǎn)臂上,俯臥位,頭向軸心,+1G z離心5 m in;D組、E組、F組、G組、H組、I組體位同C組,+10G z離心30 s,間隔時(shí)+1G z離心60 s,連續(xù)5/d,每周4d,共4周。A、B、C、D組于離心次日處死,其余各組分別于離心后1周、2周、4周、8周和12周后次日處死,取顳下頜關(guān)節(jié)、咀嚼肌、心、肝、腎等器官組織作光鏡、電鏡觀察。結(jié)果:①動(dòng)物全部成活。②A組、B組和C組器官組織未見異常;其余各組除腎臟未見明顯異常外,心臟、肝臟和顳下頜關(guān)節(jié)、咀嚼肌呈現(xiàn)不同程度病理改變,隨時(shí)間推移,上述損傷逐步減輕、呈現(xiàn)修復(fù)改變。結(jié)論:本動(dòng)物模型重復(fù)性好,實(shí)驗(yàn)證實(shí)+G z可以導(dǎo)致心臟、肝臟和顳下頜關(guān)節(jié)、咀嚼肌損傷,并能自然修復(fù),是研究+G z導(dǎo)致機(jī)體損傷和自然修復(fù)較理想的動(dòng)物模型。
[Abstract]:Objective: to establish a natural repair model of injury induced by persistent high positive acceleration (G _ z) in rats. Methods: one hundred and eight male W istar rats were randomly divided into 9 groups. 12 rats in group A. were fixed on the rotating arm of centrifuge in the position of prone position in group B, the ground of group B was fixed at 5 min ~ (-1). Head axis, 1G z centrifugation for 5 min / d group, 1 G z centrifugation for 5 min / d, 1 G z centrifugation for 5 min / d, 4 weeks / week for 4 weeks, 4 weeks / day, respectively, were killed on the second day after centrifugation, and the position of group I was the same as that of group C, 10 G z for 30 s and 1 G z for 60 s, 4 days per week, respectively, and the rats in group C were killed on the second day after centrifugation. The other groups were killed at 1 week, 2 weeks, 4 weeks, 8 weeks and 12 weeks after centrifugation. The temporomandibular joint, masticatory muscle, heart, liver, kidney and other organs were taken for light microscope. Results No abnormality was found in the organs of group B and C, except for the kidney, the heart, liver, temporomandibular joint and masticatory muscles showed pathological changes in different degrees over time. Conclusion: this animal model has good reproducibility. The experiment proved that G z can cause damage to heart, liver, temporomandibular joint, masticatory muscle, and can be repaired naturally. It is an ideal animal model to study the damage caused by G z and natural repair.
【作者單位】： 解放軍總醫(yī)院 解放軍總醫(yī)院 解放軍305醫(yī)院 解放軍總醫(yī)院 解放軍總醫(yī)院 解放軍總醫(yī)院 解放軍總醫(yī)院
【基金】：“十五”軍隊(duì)科研基金項(xiàng)目(01Q061)
【分類號(hào)】：R85

【參考文獻(xiàn)】

相關(guān)期刊論文 前2條

1 馬良,孫振宇,胡敏,姚軍,肖紅喜;顳下頜關(guān)節(jié)對(duì)不同強(qiáng)度加速度反應(yīng)的分析[J];軍醫(yī)進(jìn)修學(xué)院學(xué)報(bào);2003年02期

2 尹音!100036北京,孫振宇!100853北京,胡敏!100853北京,侯軍!100036北京,李傳兵!100036北京,李冬霞!100036北京,笪冀平!100036北京,王萍!100036北京;持續(xù)高加速度重復(fù)作用對(duì)大鼠顳下頜關(guān)節(jié)的影響[J];中華航空航天醫(yī)學(xué)雜志;2001年02期

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 戴雨,紀(jì)桂英,戴大江,王小英;正加速度對(duì)飛行員血漿降鈣素基因相關(guān)肽、內(nèi)皮素水平和腎功能的影響[J];航空軍醫(yī);1998年01期

2 符鳳英,詹皓,張政,李彤,辛益妹,韋四煌;低G預(yù)適應(yīng)對(duì)重復(fù)+10Gz應(yīng)激大鼠左心室收縮功能和心肌內(nèi)皮素與前列環(huán)素含量的影響[J];航天醫(yī)學(xué)與醫(yī)學(xué)工程;2003年06期

3 詹皓,陳立敏,辛益妹,唐桂香,溫靜;茶多酚對(duì)重復(fù)+Gz暴露大鼠腦脂質(zhì)過氧化反應(yīng)和肝腎功能的影響(英文)[J];航天醫(yī)學(xué)與醫(yī)學(xué)工程;1999年01期

4 侯公林,章志量,傅偉,吳曉山;噪聲誘發(fā)心理應(yīng)激對(duì)大白鼠組織中肌酐、尿素氮的影響[J];杭州醫(yī)學(xué)高等�？茖W(xué)校學(xué)報(bào);1999年04期

5 李茜 ,耿喜臣 ,金朝 ,王紅 ,徐艷 ,顏桂定 ,李寶輝;不同正加速度暴露下人體尿α_1-微球蛋白測(cè)定的意義[J];解放軍醫(yī)學(xué)雜志;2003年08期

6 師綠江,洪欣,任宏偉,尹昭云;金屬硫蛋白對(duì)加速度大鼠心肌氧化損傷的保護(hù)作用[J];解放軍預(yù)防醫(yī)學(xué)雜志;2004年04期

7 孫振宇,胡敏,尹音,馬良,王萍,杜平;茶多酚對(duì)+Gz過載的顳下頜關(guān)節(jié)影響分析[J];現(xiàn)代口腔醫(yī)學(xué)雜志;2002年06期

8 尹音;孫振宇;胡敏;李冬霞;蔡慶;闞廣捍;王峰;張霞;;丹參多酚酸鹽對(duì)持續(xù)性高正加速度造成大鼠顳頜關(guān)節(jié)損傷的保護(hù)作用[J];中國(guó)臨床藥理學(xué)與治療學(xué);2007年02期

9 王U，

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