【摘要】：目的:探討高溫高濕環(huán)境下大強(qiáng)度運(yùn)動(dòng)對人體血清白細(xì)胞介素12(interleukin-12,IL-12)的影響。方法:20名受試者隨機(jī)分為運(yùn)動(dòng)組和暴露組,運(yùn)動(dòng)組在溫度33℃、相對濕度分別為40%±2%(RH40%)和80%±2%(RH80%)的環(huán)境下進(jìn)行遞增負(fù)荷力竭跑臺(tái)運(yùn)動(dòng),兩次不同濕度運(yùn)動(dòng)間隔1周。跑速從8 km/h開始,每分鐘增加0.8 km/h,增加到16 km/h時(shí)不再增加,然后逐級遞增坡度,以0.5%為起始坡度,實(shí)驗(yàn)過程中以受試者不能維持相應(yīng)跑速,并自述不能堅(jiān)持時(shí)終止運(yùn)動(dòng)。暴露組在高溫中靜坐,兩者同時(shí)進(jìn)出高溫環(huán)境房。實(shí)驗(yàn)前和實(shí)驗(yàn)后即刻抽取靜脈血。采用ELISA方法檢測血清IL-12、皮質(zhì)醇。結(jié)果:運(yùn)動(dòng)組RH40%和RH80%環(huán)境下運(yùn)動(dòng)后IL-12均顯著性降低(P0.05);暴露組IL-12在RH40%暴露后出現(xiàn)降低趨勢,RH80%暴露后顯著性下降(P0.05)。運(yùn)動(dòng)組RH40%和RH80%環(huán)境下運(yùn)動(dòng)后血清皮質(zhì)醇均顯著升高(P0.01,P0.05);暴露組血清皮質(zhì)醇RH40%暴露前后無顯著性差異,RH80%暴露后顯著性降低(P0.01)。結(jié)論:高溫環(huán)境下,無論相對濕度高低,進(jìn)行遞增負(fù)荷大強(qiáng)度運(yùn)動(dòng)后血清IL-12均降低,可能由血清皮質(zhì)醇顯著升高對IL-12產(chǎn)生抑制作用所引起,但高溫環(huán)境下運(yùn)動(dòng)引起免疫抑制的機(jī)制有待研究。
[Abstract]:Objective: to study the effect of high intensity exercise on serum interleukin 12 (interleukin-12,IL-12) in high temperature and high humidity environment. Methods: twenty subjects were randomly divided into two groups: exercise group and exposed group. The exercise group performed exhaustive treadmill exercise at 33 鈩，

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