【摘要】：目的應(yīng)用定量CT(QCT)評估小兒炎癥性腸病(inflammatory bowel disease,IBD)的骨密度(bone mineral density,BMD)狀況,為IBD的治療提供依據(jù)。方法收集我院確診的IBD患兒27例,同時收集正常人群62例。應(yīng)用QCT方法測量兩組人群骨密度,結(jié)果進(jìn)行統(tǒng)計學(xué)分析。同時從中選取學(xué)齡兒童(7~12歲)的IBD患兒共12例作為病例組;按照性別、年齡、人數(shù)相匹配的原則從正常人群中選取12例作為正常對照組。對這兩組的QCT結(jié)果進(jìn)行統(tǒng)計學(xué)分析。并觀察這兩組對照結(jié)果的一致性。結(jié)果 1)0~14歲27名IBD患兒骨密度從110.9mg/cm3到201.8mg/cm3,骨密度平均值為(165.49±18.93)mg/cm3,與62名正常人群骨密度值的比較(IBD患兒低于正常人群骨密度的平均值(189.65±26.99)mg/cm3,Z=-4.07,P=0.000,P0.05,二者差異有統(tǒng)計學(xué)意義;2)克羅恩病(Crohn’s disease,CD)組患兒骨密度平均值(162.26±16.77)mg/cm3,與正常人群骨密度比較(CD組患兒低于正常人群骨密度的平均值(189.65±26.99)mg/cm3,Z=-3.261,P=0.001,P0.05,二者差異有統(tǒng)計學(xué)意義。潰瘍性結(jié)腸炎(ulcerative colitis,UC)組患兒骨密度平均值(171.97±17.11)mg/cm3,與正常人群骨密度比較〔UC組患兒低于正常人群骨密度的平均值(189.65±26.99)mg/cm3〕,Z=-1.908,P=0.056,P0.05,二者差異無統(tǒng)計學(xué)意義;3)病例組(12名7~12歲IBD患兒)的骨密度與正常對照組(12名7~12歲正常兒童)骨密度的比較:病例組骨密度平均值為(159.9±15.32)mg/cm3,正常對照組骨密度平均值為(186.96±10.97)mg/cm3,t=-4.97,P=0.000,P0.05,二者差異有統(tǒng)計學(xué)意義,且病例組骨密度低于正常對照組的骨密度。結(jié)論 IBD患兒骨密度低于同年齡正常人群骨密度;其中CD組和UC組患兒骨密度均低于正常人群骨密度,且CD組患兒比UC組患兒更易出現(xiàn)骨密度下降。使用QCT骨密度測量技術(shù)可以精確敏感的評估患兒骨密度情況,指導(dǎo)臨床進(jìn)一步的治療方案。
[Abstract]:Objective to evaluate the bone mineral density (bone mineral density,BMD) of inflammatory bowel disease (inflammatory bowel disease,IBD) by quantitative CT (QCT) and to provide evidence for the treatment of IBD. Methods 27 cases of IBD and 62 cases of normal population were collected. The bone mineral density (BMD) of the two groups was measured by QCT method, and the results were analyzed statistically. At the same time, 12 cases of school age children (7 ~ 12 years old) with IBD were selected as case group, and 12 cases of normal population were selected as normal control group according to the principle of gender, age and population matching. The QCT results of the two groups were statistically analyzed. The consistency of the control results between the two groups was observed. Results 1) the BMD of 27 IBD children aged 14 years was from 110.9mg/cm3 to 201.8mg / cm ~ (3), the average value of BMD was (165.49 鹵18.93) mg/cm3, and 62 normal subjects (the BMD of IBD children was lower than that of normal subjects (189.65 鹵26.99) mg/cm3,Z=-4.07,P=0.000,P0.05,; 2) Crohn's BMD was significantly lower than that of normal subjects (189.65 鹵26.99) mg/cm3,Z=-4.07,P=0.000,P0.05,. The average value of BMD in Crohn's disease,CD group was (162.26 鹵16.77) mg/cm3, compared with that in normal group (BMD in CD group was lower than that in normal group (189.65 鹵26.99) mg/cm3,Z=-3.261,P=0.001,P0.05,). The mean value of BMD in children with ulcerative colitis (ulcerative colitis,UC) was (171.97 鹵17.11) mg/cm3, compared with that in normal controls (BMD in UC group was lower than that in normal controls (189.65 鹵26.99 mg/cm3), and there was no significant difference between the two groups. 3) there was no significant difference between the two groups (12 IBD children aged 712 years). BMD was compared with that in the normal control group (12 normal children aged 712 years): the average BMD in the case group was (159.9 鹵15.32) mg/cm3, the average BMD in the normal control group was (186.96 鹵10.97) mg/cm3,t=-4.97,P=0.000,P0.05, there was significant difference between the two groups. The BMD in the case group was lower than that in the normal control group. Conclusion the BMD of children with IBD is lower than that of normal people of the same age, the BMD of CD group and UC group is lower than that of normal group, and the BMD of CD group is more likely to decrease than that of UC group. QCT bone density measurement can accurately and sensitively evaluate the BMD in children and guide further clinical treatment.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京兒童醫(yī)院影像中心;
【基金】：首都臨床特色應(yīng)用研究(項目編號:Z141107002514005)
【分類號】：R725.7;R816.92

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 彭利暉;胡燈明;王三斌;;兒童急性淋巴細(xì)胞性白血病治療后骨密度的變化[J];臨床軍醫(yī)雜志;2010年05期

2 李彩霞;;7863例嬰幼兒骨密度結(jié)果分析[J];中國優(yōu)生與遺傳雜志;2013年01期

3 馬揚;劉莉;;北方地區(qū)嬰幼兒骨密度發(fā)育情況分析[J];中國婦幼保健;2014年10期

4 李旭芬,朱沛,侯崗,蘇景霞,宋曉華,李娟;中國青少年與日本青少年骨密度對比分析[J];現(xiàn)代康復(fù);2001年20期

5 張海燕;;許昌市1467例0～36月兒童骨密度結(jié)果分析[J];中國現(xiàn)代藥物應(yīng)用;2011年04期

6 高桂香;班自芹;陳玲;吳茂萍;孫居勝;;孕期補鈣與小兒骨密度關(guān)系調(diào)查[J];社區(qū)醫(yī)學(xué)雜志;2012年03期

7 李曉平;;論運動與青少年骨密度[J];文體用品與科技;2013年24期

8 馮璇;周曉東;楊陽;陳海春;程小游;鐘新生;徐建清;;福州市青少年骨密度影響因素的調(diào)查分析[J];福建體育科技;2014年01期

9 王萍玉;兒童骨密度的研究進(jìn)展[J];國外醫(yī)學(xué)(婦幼保健分冊);2002年03期

10 劉俊凌;李春枝;;矮小兒童骨密度與血鋅、鈣、鐵、鉛的關(guān)系[J];實用兒科臨床雜志;2008年08期

相關(guān)碩士學(xué)位論文 前5條

1 熊昕;昆明市1～3歲幼兒骨密度影響因素分析[D];昆明醫(yī)學(xué)院;2009年

2 陳艷;八市15歲以下兒童超聲骨密度調(diào)查（2008年）[D];蘇州大學(xué);2010年

3 黃珂;不同喂養(yǎng)方式對嬰兒骨密度的影響[D];昆明醫(yī)學(xué)院;2011年

4 郭斌;正常兒童青少年的骨密度和身體成分分析[D];暨南大學(xué);2010年

5 楊景暉;成都地區(qū)漢族兒童維生素D受體基因多態(tài)性與骨密度關(guān)系研究[D];四川大學(xué);2005年

，

本文編號：2264912