【摘要】：針對(duì)現(xiàn)有核素治療中內(nèi)照射劑量測(cè)量缺乏簡(jiǎn)單、高效方法的問(wèn)題,基于內(nèi)照射劑量與切倫科夫輻射之間的關(guān)系,提出一種基于切倫科夫輻射的核素治療內(nèi)照射劑量測(cè)量的新方法。利用蒙特卡羅計(jì)算程序Geant4,模擬放射性核素131I在水體模型和甲狀腺模型中產(chǎn)生切倫科夫輻射與劑量沉積的分布情況,并定量分析切倫科夫光子數(shù)與劑量之間的關(guān)系。計(jì)算結(jié)果表明:在水體模的半徑方向上切倫科夫光子數(shù)與劑量之間有著相同的變化趨勢(shì),且兩者有著相同的二維分布規(guī)律;核素131I在介質(zhì)中產(chǎn)生的切倫科夫光子數(shù)與劑量?jī)烧咧g存在一定的線性關(guān)系,且這種線性關(guān)系與核素的分布情況無(wú)關(guān)。研究結(jié)果證實(shí),將這種放射性核素在介質(zhì)中產(chǎn)生的切倫科夫輻射應(yīng)用于內(nèi)照射劑量學(xué)具有非常大的研究潛力和價(jià)值。
[Abstract]:In view of the lack of simple and efficient methods to measure internal radiation dose in radionuclide therapy, based on the relationship between internal radiation dose and Cerenkov radiation, A new radiation dose measurement method for radionuclide therapy based on Cerenkov radiation is proposed. Monte Carlo program Geant4, was used to simulate the distribution of Cerenkov radiation and dose deposition of radionuclides 131I in water and thyroid models, and to quantitatively analyze the relationship between Cerenkov photon number and dose. The results show that there is the same variation trend between the number of Cherenkov photons and the dose in the radius direction of the water model, and they have the same two-dimensional distribution law. There is a linear relationship between the number of Cerenkov photons produced by radionuclide 131I in the medium and the dose, and this linear relationship is independent of the distribution of nuclides. The results show that the application of the Cerenkov radiation produced by the radionuclides in the medium has great potential and value in the study of internal radiation dosimetry.
【作者單位】： 南京航空航天大學(xué)核科學(xué)與工程系;江蘇省高校放射醫(yī)學(xué)協(xié)同創(chuàng)新中心;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(11475087) 南京航空航天大學(xué)研究生創(chuàng)新基地開(kāi)放基金項(xiàng)目(kfjj20160610) 江蘇省優(yōu)勢(shì)學(xué)科建設(shè)工程資助項(xiàng)目
【分類(lèi)號(hào)】：R815
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本文編號(hào)：2221962