【摘要】：目的:研究8周游泳運動對生長期大鼠棕色脂肪重量及棕色脂肪中PGC-1α的影響。方法:新生Sprague Dawley大鼠,隨機分為對照組(1 w~8 w)和運動組(1 w~8 w),運動組進行8周游泳運動。兩組均分批于每周日取材,稱量體重,取肩胛部位的棕色脂肪稱重,并測其PGC-1αm RNA水平及蛋白表達量。結(jié)果:1)隨著周齡增長,運動組體重低于對照組,在5~8周有顯著性差異;對照組棕色脂肪重量先增加后減少,運動組先增加后趨于穩(wěn)定,兩組相比,6~8周有顯著性差異;2)PGC-1αm RNA和蛋白的表達趨勢基本一致,在對照組中均表達較低,在運動組中表達較高,兩組相比具有顯著性差異。結(jié)論:游泳運動能抑制生長期后期大鼠棕色脂肪重量的下降,并促進PGC-1α高表達,導(dǎo)致適應(yīng)性產(chǎn)熱增多,這可能是游泳運動導(dǎo)致生長期大鼠體重降低的原因之一。
[Abstract]:Aim: to study the effects of swimming for 8 weeks on the weight of brown fat and PGC-1 偽 in brown fat of growing rats. Methods: newborn Sprague Dawley rats were randomly divided into control group (1 week, 8 weeks) and exercise group (1 week, 8 w), exercise group) for 8 weeks swimming. The body weight and brown fat of scapula were measured and the PGC-1 偽 m RNA level and protein expression were measured. Results: with the increase of week age, the body weight of exercise group was lower than that of control group, and there was significant difference at 5 ~ 8 weeks, the weight of brown fat in control group first increased and then decreased, while in exercise group it increased first and then stabilized. There was significant difference in the expression of PGC-1 偽 m RNA and protein between the two groups at 8 weeks. The expression of PGC-1 偽 m RNA and protein were lower in the control group and higher in the exercise group, and there was significant difference between the two groups. Conclusion: swimming exercise can inhibit the decrease of brown fat weight, promote the high expression of PGC-1 偽 and increase adaptive heat production, which may be one of the reasons for the weight loss of growing rats.
【作者單位】： 北京體育大學(xué)運動人體科學(xué)學(xué)院;國家體育總局運動醫(yī)學(xué)研究所;
【基金】：國家體育總局體育科學(xué)研究所基本科研業(yè)務(wù)費資助(基本13-11)
【分類號】：R87

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