【摘要】：目的 通過(guò)三種不同濃度的非離子型單體碘對(duì)比劑，分別行高、中、低三種劑量多層螺旋CT犬腎動(dòng)脈成像，探討低濃度低劑量對(duì)比劑在犬腎動(dòng)脈成像的可行性，為將低濃度低劑量碘對(duì)比劑應(yīng)用于臨床腎動(dòng)脈CTA成像提供實(shí)驗(yàn)依據(jù)。 材料與方法 將不同濃度的碘對(duì)比劑分成三組（A-370mgI/ml, B-350mgI/ml,C-300mgI/ml）分別進(jìn)行高、中、低三種劑量(1-2.40ml/kg,2-2.02ml/kg,3-1.62ml/kg)注射，共分為9組（A1-3、B1-3、C1-3）；對(duì)6只健康家犬以隨機(jī)原則進(jìn)行MSCT腎動(dòng)脈成像掃描分析，每組進(jìn)行8次掃描，合計(jì)72次。掃描完成后，將重建數(shù)據(jù)在工作站進(jìn)行圖像后處理。 兩名副主任以上放射科醫(yī)師，根據(jù)對(duì)原始圖像以及后處理圖像的容積重現(xiàn)（VR）、最大密度投影（MIP）、多平面重建（MPR）和曲面重建（CPR）圖像，對(duì)犬腎動(dòng)脈血管邊緣情況、血管分支顯影情況及腎實(shí)質(zhì)顯影情況進(jìn)行評(píng)分。并分別在腎動(dòng)脈主干分叉層面、主干背側(cè)分支分叉層面、主干腹側(cè)分支分叉層面、腎段動(dòng)脈分支分叉層面、葉間動(dòng)脈分支分叉層面共五個(gè)層面進(jìn)行CT值測(cè)量，每組取各層面CT值均值進(jìn)行統(tǒng)計(jì)學(xué)分析。 結(jié)果 1、兩名副主任以上醫(yī)師對(duì)犬腎動(dòng)脈邊緣顯影情況、分支顯影情況及腎實(shí)質(zhì)顯影情況的評(píng)分結(jié)果具有高度一致性，其Kappa值分別為0.781、0.773、0.783。 2、九組（A1、A2、A3、B1、B2、B3、C1、C2、C3）犬腎動(dòng)脈邊緣顯影的評(píng)分結(jié)果依次為2.73±0.31、2.75±0.30、2.69±0.32、2.82±0.39、2.71±0.28、2.68±0.30、2.75±0.35、2.66±0.29、2.77±0.40；犬腎動(dòng)脈分支顯影的評(píng)分結(jié)果依次為3.73±0.36、3.81±0.42、3.69±0.35、3.71±0.46、3.65±0.50、3.70±0.43、3.77±0.41、3.86±0.41、3.74±0.53；犬腎實(shí)質(zhì)評(píng)分結(jié)果依次為2.75±0.32、2.63±0.28、2.86±0.29、2.75±0.38、2.75±0.27、2.87±.031、2.63±0.51、2.63±0.42、2.75±0.50。各組圖像動(dòng)脈邊緣情況、分支顯影情況及腎實(shí)質(zhì)顯影情況組間兩兩比較均無(wú)顯著性差異（P0.05）。 3、犬腎動(dòng)脈不同分支血管內(nèi)的CT值測(cè)量結(jié)果顯示，A1、A2、A3；B1、B2、B3；C1、C2、C3各組組間兩兩比較具有顯著性差異（P0.05）；A1、B1、C1；A2、B2、C2；A3、B3、C3各組組間兩兩比較無(wú)顯著性差異（P0.05）。 結(jié)論 應(yīng)用低濃度低劑量碘對(duì)比劑進(jìn)行MSCT犬腎動(dòng)脈CTA成像掃描，可以得到腎動(dòng)脈的優(yōu)質(zhì)圖像，為將低濃度低劑量碘對(duì)比劑應(yīng)用于臨床腎動(dòng)脈CTA成像奠定了基礎(chǔ)。
[Abstract]:Objective to evaluate the feasibility of three different concentrations of Nonionic iodide contrast agents in canine renal artery imaging with high, medium and low doses of multi-slice spiral CT. To provide experimental evidence for the application of low concentration and low dose iodine contrast agent in renal artery CTA imaging. Materials and methods different concentrations of iodine contrast agents were divided into three groups (A-370mgI / ml, B-350mgIml-1 / ml, C-300mgIr / ml) and injected with high, middle and low doses (1-2.40ml / kg2-2.02ml / kg / kg 3-1.62ml / kg), and were divided into 9 groups (A1-3Mg-B1-3C1-3). Each group was scanned 8 times, total 72 times. After the scan is completed, the reconstructed data is processed on the workstation. According to the volume rendering (VR), maximum density projection (MIP), multiplanar reconstruction (MPR) and curved surface reconstruction (CPR) of the original and post-processed images, two radiologists or above were used to evaluate the edge of the renal artery in canine renal artery, according to the volume rendering (VR), maximum intensity projection (MIP), multiplanar reconstruction (MPR) and curved surface reconstruction (CPR). The development of vascular branches and renal parenchyma were evaluated. The CT values were measured on five layers: the main branch of the renal artery, the dorsal branch of the main trunk, the ventral branch of the main trunk, the branch of the renal segment and the interlobar artery. The CT values of each group were statistically analyzed. Results 1. There was a high consistency among the scores of the edge of renal artery, branch development and renal parenchyma of two or more deputy chief physicians. 鍏禟appa鍊煎垎鍒負(fù)0.781,0.773,0.783. 2,涔?jié)缁?A1,A2,A3,B1,B2,B3,C1,C2,C3)鐘偩鍔ㄨ剦杈圭紭鏄懼獎(jiǎng)鐨勮瘎鍒嗙粨鏋滀緷嬈′負(fù)2.73鹵0.31,2.75鹵0.30,2.69鹵0.32,2.82鹵0.39,2.71鹵0.28,2.68鹵0.30,2.75鹵0.35,2.66鹵0.29,2.77鹵0.40錛涚姮鑲懼姩鑴夊垎鏀樉褰辯殑璇勫垎緇撴灉渚濇涓，

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