本文選題：金匱腎氣丸 + 運(yùn)動(dòng)　； 參考：《曲阜師范大學(xué)》2012年碩士論文

【摘要】：1研究目的 通過(guò)對(duì)訓(xùn)練大鼠灌服金匱腎氣丸，觀察該中成藥對(duì)運(yùn)動(dòng)訓(xùn)練中老年大鼠的腎臟功能指標(biāo)變化的影響，探討金匱腎氣丸和運(yùn)動(dòng)對(duì)提高中老年大鼠腎功能的作用，為更好的指導(dǎo)中老年人健身提供科學(xué)依據(jù)。 2研究方法 選取雌性Wister老年大鼠80只將其隨機(jī)分成8組，即對(duì)照組、安靜服藥組、20min運(yùn)動(dòng)組、40min運(yùn)動(dòng)組、60min運(yùn)動(dòng)組、20min運(yùn)動(dòng)服藥組、40min運(yùn)動(dòng)服藥組、60min運(yùn)動(dòng)服藥組，并將10只6周齡大鼠作為青年組對(duì)照組。 運(yùn)動(dòng)組和運(yùn)動(dòng)服藥組大鼠經(jīng)8周跑臺(tái)訓(xùn)練，安靜服藥組和運(yùn)動(dòng)服藥組每天灌服一定劑量的金匱腎氣丸液。8周后于相應(yīng)時(shí)刻摘眼球取血后并取腎臟組織測(cè)定尿素氮、血清肌酐、尿酸、SOD、MDA。所有數(shù)據(jù)用SPSS17.0統(tǒng)計(jì)軟件進(jìn)行單因素方差分析和T檢驗(yàn)，顯著性水平為P0.05。 3實(shí)驗(yàn)結(jié)果 3.1血清中尿素氮的含量，服藥組、40min運(yùn)動(dòng)組和40min運(yùn)動(dòng)服藥組極顯著低于對(duì)照組（P㩳0.01），青年組和20min運(yùn)動(dòng)組顯著低于對(duì)照組（P㩳0.05），40min運(yùn)動(dòng)服藥組顯著低于20min運(yùn)動(dòng)服藥組和60min運(yùn)動(dòng)服藥組（P㩳0.05）。 3.2血清肌酐的含量，服藥組顯著低于對(duì)照組（P㩳0.05），青年組、40min運(yùn)動(dòng)組、40min運(yùn)動(dòng)服藥組極顯著低于對(duì)照組（P㩳0.01），40min運(yùn)動(dòng)服藥組顯著低于服藥組（P㩳0.05），40min運(yùn)動(dòng)服藥組極顯著低于20min運(yùn)動(dòng)服藥組和60min運(yùn)動(dòng)服藥組（P㩳0.01）。 3.3血清尿酸的含量，安靜服藥組、40min運(yùn)動(dòng)組、20min運(yùn)動(dòng)服藥組和40min運(yùn)動(dòng)服藥組顯著低于對(duì)照組（P㩳0.05），60min運(yùn)動(dòng)組顯著高于對(duì)照組（P㩳0.05），青年組極顯著低于對(duì)照組（P㩳0.01），20min運(yùn)動(dòng)組和40min運(yùn)動(dòng)組顯著低于60min運(yùn)動(dòng)組（P㩳0.05），40min運(yùn)動(dòng)服藥組顯著低于60min運(yùn)動(dòng)服藥組（P㩳0.05），20min運(yùn)動(dòng)組和40min運(yùn)動(dòng)組無(wú)明顯差異(P0.05)，20min運(yùn)動(dòng)服藥組和40min運(yùn)動(dòng)服藥組無(wú)明顯差異(P0.05)。 3.4腎組織中SOD活性，青年組、40min運(yùn)動(dòng)服藥組和60min運(yùn)動(dòng)服藥組極顯著高于對(duì)照組（P㩳0.01），安靜服藥組和20min運(yùn)動(dòng)服藥組顯著高于對(duì)照組（P㩳0.05），60min運(yùn)動(dòng)服藥組顯著高于60min運(yùn)動(dòng)組（P㩳0.05），40min運(yùn)動(dòng)服藥組顯著高于40min運(yùn)動(dòng)組（P㩳0.05）。 3.5腎組織中MDA的含量，青年組、安靜服藥組、20min運(yùn)動(dòng)服藥組和40min運(yùn)動(dòng)服藥組極顯著低于對(duì)照組（P㩳0.01），40min運(yùn)動(dòng)組和60min運(yùn)動(dòng)組顯著低于對(duì)照組（P㩳0.05），60min運(yùn)動(dòng)組顯著高于20min運(yùn)動(dòng)組（P㩳0.05），60min運(yùn)動(dòng)組極顯著高于40min運(yùn)動(dòng)組（P㩳0.01），20min運(yùn)動(dòng)服藥組顯著低于60min運(yùn)動(dòng)服藥組（P㩳0.05），40min運(yùn)動(dòng)服藥組極顯著低于60min運(yùn)動(dòng)服藥組（P㩳0.01）。 4結(jié)論 4.1金匱腎氣丸和適量運(yùn)動(dòng)能夠降低大鼠血清中尿素氮、肌酐和尿酸的含量，使老年大鼠腎小球的濾過(guò)功能提高，對(duì)腎保護(hù)有積極作用。 4.2金匱腎氣丸和適量運(yùn)動(dòng)能夠降低大鼠腎臟組織中MDA含量，提高腎臟組織中SOD的活性，抑制脂質(zhì)過(guò)氧化，增強(qiáng)機(jī)體抗氧化能力。 4.3金匱腎氣丸結(jié)合運(yùn)動(dòng)訓(xùn)練對(duì)于老年大鼠腎功能的保護(hù)，，較之單純服藥和單純運(yùn)動(dòng)訓(xùn)練效果更加明顯。
[Abstract]:Objective to observe the effect of Jinkui Shenqi pills on the changes of renal function in middle-aged and aged rats during exercise training by taking Jinkui Shenqi pills in training rats. To explore the effect of Jinkui Shenqi pills and exercise on improving renal function in middle-aged and aged rats. Methods 80 female Wister aged rats were randomly divided into 8 groups, namely the control group. The control group consisted of 10 6-week-old rats in the control group, and 10 rats aged 6 weeks were used as the control group, and 10 rats in the control group were used as the control group, and 10 rats in the 6-week old group were used as the control group, and 10 rats in the 6-week-old group were used as the control group. Rats in exercise group and exercise medication group were trained by running platform for 8 weeks. Rats in quiet medication group and exercise medication group were given a certain dose of Jinkui Shenqi pills daily. After 8 weeks, blood was taken from eyeball and kidney tissue was taken to measure urea nitrogen and serum creatinine. MDAs. All the data were analyzed by single factor ANOVA and T test with SPSS 17.0 statistical software. The significant level of all data was P0.05.3 results 3.1 the content of urea nitrogen in serum. The serum creatinine levels in the 40 minutes exercise group and the 40min exercise group were significantly lower than those in the control group. The serum creatinine levels in the young group and the 20min group were significantly lower than those in the control group. The serum creatinine levels in the control group were significantly lower than those in the 20min exercise group and the 60min exercise group. The treatment group was significantly lower than the control group (P 0.05), the young group was significantly lower than the control group (P 0.01) and the control group was significantly lower than that of the control group (P 0.05) and the control group was significantly lower than that of the control group (P < 0.01). The level of P0. 01 was significantly lower in the control group than in the control group (P < 0 05). The level of P0.01 in the 40 min exercise group was significantly lower than that in the control group (P < 0 05). 3.3 level of serum uric acid, The exercise group and the 40min group were significantly lower than those in the control group (P < 0.05), the young group was significantly lower than the control group (P < 0.01) and the 40min exercise group was significantly lower than that in the 60min exercise group (P 0.05min), while the control group was significantly lower than that in the control group (P < 0.01) and the 40min exercise group was significantly lower than that in the control group (P < 0.01) and the control group was significantly lower than that in the control group (P < 0.01) and the control group was significantly lower than that in the control group. There was no significant difference between the exercise group and the 40min group. There was no significant difference between the exercise group and the 40min group. There was no significant difference in the activity of sod in the renal tissue between the exercise group and the 40min group, and there was no significant difference in the activity of sod in the renal tissue between the exercise group and the 40min group. The 40 minutes exercise medication group and the 60min exercise medication group in the young group were significantly higher than those in the control group, while the rest group and the 20min exercise group were significantly higher than the control group in the control group, which were significantly higher than those in the 60min exercise group and the 40 minutes exercise group, which were significantly higher than those in the 60min exercise group, which were significantly higher than those in the control group, and that in the rest group and the 20min exercise group were significantly higher than those in the control group. The content of MDA in renal tissue of P0. 05 and 3. 5 in control group, Youth group, 20 minutes exercise group and 40min exercise medication group were significantly lower than those in control group (P < 0.01) and 60min group (P < 0.01). The exercise group was significantly lower than the control group (P < 0.05). The exercise group was significantly higher than that in the 20min exercise group (P < 0.05) and the 40min exercise group was significantly higher than that in the 40min exercise group (P < 0.05), which was significantly lower than that in the control group (P < 0.05), which was significantly lower than that in the control group (P < 0.05). The treatment group was significantly lower than that of the 60min exercise group (P 0.05) and the 40 min exercise group was significantly lower than that of the 60min exercise group (P < 0.01). Conclusion 4.1 Jingui Shenqi pills and moderate exercise can reduce the urea nitrogen in the serum of rats. The contents of creatinine and uric acid increased the glomerular filtration function of aged rats and played a positive role in renal protection. 4.2 Jingui Shenqi pills and moderate exercise could decrease the content of MDA and increase the activity of SOD in renal tissue. 4.3 the protective effect of Jingui Shenqi pills combined with exercise training on the renal function of aged rats was more obvious than that of taking medicine alone and exercise training alone.
【學(xué)位授予單位】：曲阜師范大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：G804.2;R285.5

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