本文選題：硬化蛋白抗體 + 跑臺運動�。� 參考：《中國骨質(zhì)疏松雜志》2016年06期

【摘要】：目的探討硬化蛋白抗體和跑臺運動對老齡去勢大鼠骨重建的影響。方法 8月齡雌性Wistar大鼠,按體質(zhì)量隨機分層分為5組:Sham組(假手術(shù)組)、OVX組(去卵巢組)、OVX+E組(去卵巢+運動組)、OVX+S組(去卵巢+硬化蛋白抗體組)、OVX+E+S組(去卵巢+運動+硬化蛋白抗體組)。在14w后取材進行相關(guān)指標(biāo)測試。結(jié)果 1單純性的運動鍛煉能降低脂肪量,增加骨小梁數(shù)目,減少骨吸收標(biāo)記物NTx水平,防止老齡去勢大鼠全身、股骨骨密度發(fā)生下降。2單純性的硬化蛋白抗體治療能增加骨形成標(biāo)志物OC,提高去勢大鼠的皮質(zhì)孔隙率、皮質(zhì)骨體積和皮質(zhì)骨厚度,提高骨密度。3運動與硬化蛋白抗體交互作用時,可以降低脂肪量,提高骨密度和皮質(zhì)骨參數(shù),增加骨量和骨強度,提高OC水平、降低NTx水平。結(jié)論適度的跑臺運動可以防止老齡去勢大鼠骨量丟失,改善去勢大鼠骨健康。硬化蛋白抗體療法可以增加皮質(zhì)骨骨量和骨強度,預(yù)防去勢大鼠絕經(jīng)后對骨代謝的不良影響。硬化蛋白和運動表現(xiàn)出良好的協(xié)同作用,對老齡去勢大鼠骨重建具有積極的作用。
[Abstract]:Objective to investigate the effects of sclerosin antibody and treadmill exercise on bone reconstruction in aged ovariectomized rats. Methods 8-month-old female Wistar rats were used. They were randomly divided into 5 groups according to their body weight: OVX group (sham operation group) (ovariectomized group OVX E group (ovariectomized group) OVX S group (ovariectomized protein antibody group) OVX E S group (ovariectomized motor sclerosing protein antibody group). The related indexes were tested after 14 weeks. Results 1 simple exercise could reduce fat, increase the number of trabeculae, decrease the level of bone resorption marker NTX, and prevent the whole body of aged castrated rats. Osteogenesis of femur decreased by .2 simple anti-sclerosing protein antibody treatment increased bone formation marker OC, increased cortical porosity, cortical bone volume and cortical bone thickness in ovariectomized rats. When the interaction between exercise and sclerosing protein antibody was increased, the fat content was decreased, bone density and cortical bone parameters were increased, bone mass and bone strength were increased, OC level was increased and NTX level was decreased. Conclusion moderate treadmill exercise can prevent bone loss and improve bone health of ovariectomized rats. Sclerosing protein antibody therapy can increase cortical bone mass and bone strength and prevent the adverse effects on bone metabolism after menopause in ovariectomized rats. Sclerosing protein and exercise showed good synergistic effect, and had positive effect on bone reconstruction in aged ovariectomized rats.
【作者單位】： 上海體育學(xué)院;
【分類號】：R87

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