本文選題：CT + 彈性壁　； 參考：《新疆大學(xué)》2017年碩士論文

【摘要】：目的構(gòu)建顱內(nèi)動(dòng)脈瘤的數(shù)值模型,并對(duì)數(shù)值模型進(jìn)行優(yōu)化處理,以期為后續(xù)支架設(shè)計(jì)以及支架介入實(shí)驗(yàn)提供良好的模型參數(shù)。分析動(dòng)脈瘤破裂、出血的幾何外觀因素,為臨床上動(dòng)脈瘤破裂的風(fēng)險(xiǎn)評(píng)判提供一定的參數(shù)標(biāo)準(zhǔn)。方法利用三維CT技術(shù)建立患者腦動(dòng)脈瘤三維模型,然后結(jié)合計(jì)算流體力學(xué)軟件ANSYS CFX15.0構(gòu)建動(dòng)脈瘤數(shù)值模型。對(duì)比分析不同條件下,如剛性壁和彈性壁、瘤體壁厚與動(dòng)脈血管壁厚一致與否、牛頓和非牛頓流體、動(dòng)脈血管入口與出口長(zhǎng)度不一、不同楊氏模量情況下瘤腔內(nèi)血流場(chǎng)變化情況。對(duì)于動(dòng)脈瘤破裂的幾何因素,選取83例動(dòng)脈瘤患者CT數(shù)據(jù),建立三維模型,測(cè)量模型的幾何外觀參數(shù)。運(yùn)用統(tǒng)計(jì)學(xué)軟件spss23.0,對(duì)破裂動(dòng)脈瘤與未破裂動(dòng)脈瘤幾何尺寸進(jìn)行統(tǒng)計(jì)分析。結(jié)果彈性壁模型相較于剛性壁,剛性壁最大變形量約占管徑13%,同比下彈性壁變形量約占管徑7.5%。剛性壁變形量約是彈性壁的2.4倍。牛頓與非牛頓模型血流場(chǎng)參數(shù)相差不大,最大約為2.19%。動(dòng)脈瘤璧與動(dòng)脈血管壁厚度分開定義與不分開定義的模型,瘤體壁面變形差異較大,約為43%。動(dòng)脈血管壁的變形量隨著楊氏模量的增加而減小。動(dòng)脈瘤出口長(zhǎng)度不變時(shí),入口長(zhǎng)度過(guò)短時(shí),瘤腔內(nèi)渦流不明顯,隨著入口長(zhǎng)度的增加渦流現(xiàn)象加劇,到最后穩(wěn)定在一定長(zhǎng)度內(nèi)。入口長(zhǎng)度保持不變,出口長(zhǎng)度不一時(shí),兩組模型流場(chǎng)差異不大。對(duì)破裂動(dòng)脈瘤與未破裂動(dòng)脈瘤幾何外觀尺寸統(tǒng)計(jì)發(fā)現(xiàn),AR,最大瘤寬、射出角、以及載瘤動(dòng)脈夾角P0.05,有統(tǒng)計(jì)學(xué)意義,其他參數(shù)均無(wú)統(tǒng)計(jì)學(xué)意義。對(duì)AR、瘤寬、射出角和載瘤動(dòng)脈夾角進(jìn)行受試者工作特性曲線,簡(jiǎn)稱ROC曲線分析,得出四者的最佳診斷界值分別為1.4835(靈敏度80%,特異度41.9%),5.3(靈敏度100%,特異度18.6%)、34.5(靈敏度75%,特異度37.2%)。載瘤動(dòng)脈夾角ROC曲線分析,曲線下區(qū)域面積即AUC為0.2380.5,不具有診斷意義。最終得出瘤寬、AR、射出角三者診斷效能為瘤寬AR射出角。
[Abstract]:Objective to construct a numerical model of intracranial aneurysm and optimize the model so as to provide a good model parameter for the subsequent stent design and stent intervention experiment. The geometric appearance factors of ruptured aneurysm and hemorrhage were analyzed to provide a certain parameter standard for evaluating the risk of ruptured aneurysm clinically. Methods Three-dimensional CT technique was used to establish a three-dimensional model of cerebral aneurysm, and then a numerical model of aneurysm was constructed with ANSYS CFX 15.0 software. Under different conditions, such as rigid wall and elastic wall, the thickness of tumor wall is consistent with the thickness of arterial vessel wall, Newton and non-Newtonian fluid, the length of artery inlet and outlet are different. Changes of blood flow field in tumor cavity under different Young's modulus. For the geometric factors of aneurysm rupture, the CT data of 83 patients with aneurysm were selected, the 3D model was established and the geometric appearance parameters of the model were measured. The geometric dimensions of ruptured and unruptured aneurysms were analyzed by SPSS 23.0. Results compared with the rigid wall, the maximum deformation of the rigid wall is about 13% of the diameter of the tube, and the deformation of the elastic wall is about 7.5% of the diameter of the tube. The deformation of rigid wall is about 2.4 times that of elastic wall. The parameters of blood flow field of Newtonian model and non-Newtonian model are similar, the maximum is about 2.19. The wall deformation of the aneurysm is different from that of the thickness of the artery wall, which is about 43%. The deformation of arterial wall decreased with the increase of Young's modulus. When the length of aneurysm outlet is constant, the eddy current is not obvious when the inlet length is too short, and the eddy current phenomenon intensifies with the increase of inlet length, and is stabilized within a certain length at last. When the inlet length remains constant and the outlet length is different, there is little difference between the two groups. The geometric appearance and size of ruptured aneurysms and unruptured aneurysms were statistically significant, but no statistical significance was found in other parameters, such as the maximum width of aneurysm, the angle of ejection, and the angle of aneurysm carrier artery (P0.05). The operating characteristic curves (ROC curve) of ARs, tumor width, ejection angle and angle of aneurysm carrying artery were analyzed. The results showed that the best diagnostic threshold of the four patients was 1.4835 (sensitivity 80, specificity 41.9) 5.3 (sensitivity 100, specificity 18.60.34. 5) (sensitivity 75, specificity 37.2). The analysis of the ROC curve showed that the area under the curve was 0.2380.5, which had no diagnostic significance. Finally, the diagnostic efficacy of the tumor width ARs and the ejection angle is the tumor width AR ejection angle.
【學(xué)位授予單位】：新疆大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R743;R816.1

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 郭俊;沈下賢;張必利;朱嘉琦;趙仙先;;可降解支架現(xiàn)狀及研究進(jìn)展[J];介入放射學(xué)雜志;2016年02期

2 孫瑜;楊碧林;何明江;;64排螺旋CT血管造影對(duì)顱內(nèi)動(dòng)脈瘤破裂風(fēng)險(xiǎn)的評(píng)估價(jià)值[J];中國(guó)腫瘤臨床與康復(fù);2014年06期

3 鄭河榮;劉家好;何玲娜;;腦血管計(jì)算機(jī)模型的建立與有限元分析[J];浙江工業(yè)大學(xué)學(xué)報(bào);2014年03期

4 劉波;謝鵬;李志偉;;復(fù)雜顱內(nèi)動(dòng)脈瘤的流固耦合模型的建模方法[J];重慶醫(yī)科大學(xué)學(xué)報(bào);2014年09期

5 劉波;李志偉;;數(shù)值模擬描述血管壁厚度對(duì)復(fù)雜顱內(nèi)動(dòng)脈瘤流固耦合分析結(jié)果的影響[J];中國(guó)組織工程研究;2014年11期

6 姜克文;;血管內(nèi)支架介入治療顱內(nèi)寬頸動(dòng)脈瘤臨床分析[J];中國(guó)實(shí)用神經(jīng)疾病雜志;2013年08期

7 邱曉寧;費(fèi)智敏;王煒哲;曹兆敏;;顱內(nèi)動(dòng)脈瘤夾閉手術(shù)的血流動(dòng)力學(xué)數(shù)值分析[J];生物醫(yī)學(xué)工程學(xué)雜志;2012年01期

8 吳永發(fā);沈潔;黃清海;劉建民;;不同栓塞程度對(duì)顱內(nèi)動(dòng)脈瘤介入治療后囊內(nèi)血流動(dòng)力學(xué)影響的數(shù)值模擬研究[J];第二軍醫(yī)大學(xué)學(xué)報(bào);2012年02期

9 李良;莫大鵬;張瑩;;后交通動(dòng)脈動(dòng)脈瘤夾閉術(shù)中瘤夾的選擇和應(yīng)用[J];中國(guó)腦血管病雜志;2012年02期

10 劉磊;許百男;王芙昱;王君;;顱內(nèi)動(dòng)脈瘤血流動(dòng)力學(xué)的計(jì)算流體動(dòng)力學(xué)數(shù)值模擬研究[J];臨床神經(jīng)外科雜志;2011年01期

相關(guān)會(huì)議論文 前1條

1 王盛章;陳家亮;魯剛;張曉龍;;具有病人特異性的腦動(dòng)脈瘤非牛頓流體血流動(dòng)力學(xué)研究[A];中國(guó)力學(xué)學(xué)會(huì)學(xué)術(shù)大會(huì)'2009論文摘要集[C];2009年

相關(guān)博士學(xué)位論文 前7條

1 萬(wàn)子昂;基于患者特征的顱內(nèi)動(dòng)脈瘤破裂相關(guān)危險(xiǎn)因素研究[D];浙江大學(xué);2015年

2 邱曉寧;顱頸動(dòng)脈植入支架后的血流動(dòng)力學(xué)數(shù)值模擬與PIV實(shí)驗(yàn)研究[D];上海交通大學(xué);2014年

3 馬宏偉;顱內(nèi)動(dòng)脈瘤的病理和計(jì)算流體力學(xué)研究[D];中國(guó)人民解放軍醫(yī)學(xué)院;2014年

4 顧大群;顱內(nèi)動(dòng)脈瘤血管內(nèi)治療臨床研究[D];南方醫(yī)科大學(xué);2013年

5 張p，

本文編號(hào)：2005401