本文選題：有氧運(yùn)動 + 抗阻運(yùn)動�。� 參考：《北京體育大學(xué)》2015年博士論文

【摘要】：目的：比較相同運(yùn)動時(shí)間、頻率和強(qiáng)度下有氧和抗阻運(yùn)動對糖尿病前期(IGR)人群糖調(diào)節(jié)的影響及其機(jī)制,為該人群運(yùn)動干預(yù)的具體指導(dǎo)原則和實(shí)施方案提供理論和實(shí)踐基礎(chǔ),以期通過個(gè)性化運(yùn)動處方的應(yīng)用,改善、甚至逆轉(zhuǎn)IGR人群的糖調(diào)節(jié)異常,達(dá)到預(yù)防或延緩糖尿病的目的。方法：隨機(jī)對照實(shí)驗(yàn)。將符合本研究納入、排除標(biāo)準(zhǔn)的IGR研究對象隨機(jī)分為有氧、抗阻和對照三組,分別進(jìn)行健康教育和12周的運(yùn)動干預(yù)后隨訪。結(jié)果：1、參與本研究的IGR人群有81.4%腰圍超標(biāo)(各組均值88.55-89.13cm),超重和肥胖率為55.7%(各組BMI均值24.49-25.06 kg/m2)；個(gè)體HOMA2-IR均1,90.9%的IFG人群HOMA2-β下降,82.9%的IGT人群HOMA2-β正常；各組平均IL-6和COR均高于正常值。2、有氧和抗阻組FPG和OGTT 2hPG干預(yù)前后和與對照組比較下降均有顯著性差異,血糖轉(zhuǎn)陰率有氧組與對照組之間有非常顯著性差異,GSP下降率抗阻組個(gè)體差異較大且與對照組之間有非常顯著性差異。3、有氧組IGR人群BMI和腰圍干預(yù)前后和與對照組比較下降均有顯著性差異,且其BMI與FPG干預(yù)前后的變化率呈中度正相關(guān)；有氧和抗阻組IGR人群FINS和HOMA2-IR干預(yù)前后和與對照組比較下降均有顯著性差異,其中抗阻組(特別在IGT人群中)下降幅度更大,但HOMA2-β、體成分、FFA、LEP、ADP、CRP、TNF-α、IL-6、 COR、FGF-21和GLP-1組間均無顯著性差異。結(jié)論：1、本研究IGR人群肥胖不明顯,但均存在IR；β細(xì)胞功能IFG人群多下降,IGT人群大多正常；平均IL-6和皮質(zhì)醇水平升高。2、對糖調(diào)節(jié)的影響：有氧或抗阻運(yùn)動均可使IGR人群空腹和OGTT2h血糖顯著下降,并一定程度地降至正常,但對GSP影響不明顯,其中抗阻運(yùn)動對GSP影響的個(gè)體差異較大,可使較多個(gè)體GSP得到改善。3、改善糖調(diào)節(jié)的機(jī)制探討：有氧運(yùn)動能降低IGR人群的體重和腰圍,并通過降低BMI降低空腹血糖。有氧或抗阻運(yùn)動均能改善IGR人群的IR,且抗阻運(yùn)動對FINS和IR的改善作用比有氧運(yùn)動更突出,但兩種運(yùn)動對肥胖相關(guān)細(xì)胞因子均無明顯影響,推測運(yùn)動特別是抗阻運(yùn)動對該人群糖調(diào)節(jié)的改善可能與肥胖和肥胖相關(guān)因子關(guān)系不大。
[Abstract]:Objective: to compare the effect and mechanism of aerobic and resistance exercise on glucose regulation in pre-diabetic IGR population under the same exercise time, frequency and intensity, so as to provide theoretical and practical basis for specific guiding principles and implementation schemes of exercise intervention in this population. Through the application of individualized exercise prescription, the abnormal glucose regulation of IGR population can be improved or even reversed, and the purpose of preventing or delaying diabetes can be achieved. Methods: a randomized controlled trial. The subjects of IGR were randomly divided into three groups: aerobic, resistance and control groups. The subjects were followed up after 12 weeks exercise intervention and health education respectively. Results in the study, 81.4% of the IGR participants were in excess of waist circumference (mean 88.55-89.13 cm), the overweight and obesity rates were 55.7 (BMI mean 24.49-25.06 kg 路m ~ 2 路m ~ (2), and the HOMA2- 尾 decreased by 82.9% in the IGT population with 90.9% HOMA2-IR. The average IL-6 and COR of each group were higher than the normal value of 0.2. The FPG and OGTT 2hPG decreased significantly in aerobic and resistant groups before and after the intervention and compared with the control group. There was significant difference in blood glucose conversion rate between aerobic group and control group. The individual difference of blood glucose conversion rate between aerobic group and control group was significant. 3. The BMI and waist circumference of IGR group in aerobic group were different from those in control group before and after intervention and before and after intervention with control group. There were significant differences between the two groups. The change rate of FINS and HOMA2-IR in aerobic and resistant IGR group was significantly lower than that in control group before and after the intervention of FINS and HOMA2-IR, especially in the IGT group, and the decrease was more significant in the resistant group than in the control group, especially in the IGT group, and there was a significant difference between the two groups before and after the intervention, especially in the IGT group. However, there was no significant difference in HOMA2- 尾, FFA-LEPP-ADP, TNF- 偽 IL-6, Corn FGF-21 and GLP-1 between the two groups. Conclusion: 1, the IGR population in this study is not obese, but all of them have IR.The 尾 -cell function IFG population is mostly normal, and the 尾 -cell function IFG population is mostly normal. The effect of IL-6 and cortisol on glucose regulation: aerobic or resistance exercise could significantly decrease fasting and OGTT2h blood glucose in IGR population, but had no significant effect on GSP. The effects of resistance exercise on GSP were different among individuals, which could improve GSP of more individuals. The mechanism of improving glucose regulation was discussed: aerobic exercise could reduce body weight and waist circumference of IGR population, and decrease fasting blood glucose by decreasing BMI. Both aerobic exercise and resistance exercise could improve IRI in IGR population, and the effects of resistance exercise on FINS and IR were more significant than aerobic exercise, but neither exercise had any significant effect on the cytokines associated with obesity. It is speculated that the improvement of glucose regulation by exercise, especially resistance exercise, may not be related to obesity and obesity related factors.
【學(xué)位授予單位】：北京體育大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2015
【分類號】：R87

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 陳益山;;運(yùn)動強(qiáng)度對糖尿病周圍神經(jīng)病變患者血漿NF-κB TNF-α水平的影響[J];中國實(shí)用神經(jīng)疾病雜志;2014年11期

，

本文編號：1948939