本文選題：老年患者 + 食管腫瘤��； 參考：《中華全科醫(yī)學(xué)》2016年09期

【摘要】：目的探討適形調(diào)強(qiáng)放療與常規(guī)放療治療80歲以上老年人食管癌的療效及毒副反應(yīng)。方法回顧性分析2009年11月—2012年10月收住腫瘤放療科并完成根治性放射治療的80歲以上食管癌患者共41例。其中適形調(diào)強(qiáng)放療18例,常規(guī)放療23例,總處方劑量DT 48~69 Gy,24~34次完成。統(tǒng)計2組的近期、遠(yuǎn)期療效、癥狀緩解率及毒副反應(yīng)。采用Kaplan-Meier法和Log-rank法分析比較生存率。結(jié)果適形調(diào)強(qiáng)組、常規(guī)放療組近期有效率分別為88.9%、60.9%(χ~2=4.308,P=0.044);中位生存期分別為12個月和9個月,其1年、3年生存率分別為44.4%(8/18)、21.7%(5/23)和16.7%(3/18)、4.3%(1/23)(χ~2=5.919,P=0.015)。適形調(diào)強(qiáng)組癥狀緩解率83.3%(15/18),常規(guī)放療組癥狀緩解率82.6%(19/23),2組比較差異無統(tǒng)計學(xué)意義(χ~2=0.004,P=0.951)。在毒副反應(yīng)方面,主要不良反應(yīng)為Ⅰ~Ⅱ度放射性食管炎、放射性肺炎、骨髓抑制及食欲減退,2組均未出現(xiàn)3級以上放療反應(yīng)。結(jié)論對于80歲以上食管癌患者,放射治療是一種安全有效的治療手段,采用適形調(diào)強(qiáng)放射治療可以進(jìn)一步提高療效。
[Abstract]:Objective to evaluate the efficacy and side effects of conformal intensity modulated radiotherapy (IMRT) and conventional radiotherapy in the treatment of esophageal cancer over 80 years old. Methods from November 2009 to October 2012, 41 patients with esophageal cancer over 80 years old who received radiotherapy for cancer and completed radical radiotherapy were retrospectively analyzed. There were 18 cases of conformal intensity modulated radiotherapy and 23 cases of conventional radiotherapy. The total prescription dose of DT4869 Gyrone 2434 times was completed. The short-term, long-term effects, remission rate and side effects of the two groups were analyzed. The survival rate was analyzed by Kaplan-Meier method and Log-rank method. Results in the conformal intensity control group, the short-term effective rates of conventional radiotherapy group were 88.9 and 60.9 (蠂 ~ (24) 308p ~ (0.044), the median survival time was 12 months and 9 months, respectively. The 1-year and 3-year survival rates were 44.44 / 18 / 21. 7 / 23 and 16. 733 / 18 / 4.323 (蠂 ~ (2 / 2) 5.919 / P 0.015), respectively. There was no significant difference in the remission rate of symptoms between the conformal intensity control group (83.3 / 18) and the conventional radiotherapy group (82.6 / 23 / 23) (蠂 ~ (2 / 2) 0.004 / P ~ (0.951). The main adverse reactions were radiation esophagitis, radiation pneumonia, bone marrow suppression and anorexia. There was no radiation reaction above grade 3 in group 鈪，

本文編號：1935051