本文選題：放射性直腸炎 + 美沙拉嗪��； 參考：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:觀察美沙拉嗪口服聯(lián)合栓劑治療放射性直腸炎的臨床療效。方法:收集2014年9月~2017年1月于山西醫(yī)科大學(xué)第一醫(yī)院就診,接受腹、盆部腫瘤放射治療后發(fā)生放射性直腸炎的患者。所有患者均給予美沙拉嗪腸溶片,1g,Tid,Po;美沙拉嗪栓,0.5g,Qd,塞肛,治療總療程為5周。觀察治療后總有效率,治療前后各癥狀積分、生活質(zhì)量及血象的變化情況,并對內(nèi)鏡下腸黏膜損傷的情況進(jìn)行評價(jià),同時(shí)記錄藥物的不良反應(yīng)。結(jié)果:1、美沙拉嗪口服聯(lián)合栓劑治療放射性直腸炎,臨床治愈例數(shù)占25%,顯效65%,無效10%,總有效率達(dá)90%。2、治療后患者便血、大便次數(shù)增多及醫(yī)師對癥狀的整體評價(jià)的癥狀積分較治療前明顯改善(P0.05);腹痛、里急后重及炎癥引起的發(fā)熱治療前后,差異不明顯(P0.05)。3、治療后KPS評分及PLT值均較治療前明顯提高(P0.05)。4、腸鏡下黏膜損傷情況,治療后明顯減輕,差異有統(tǒng)計(jì)學(xué)意義(P0.01)。5、整個(gè)觀察期間,患者未發(fā)生明顯不良反應(yīng)。結(jié)論:美沙拉嗪口服聯(lián)合栓劑治療放射性直腸炎,可改善臨床癥狀和提高生活質(zhì)量,尤其是對大便次數(shù)增多及便血的療效顯著,且具有良好的安全性。
[Abstract]:Objective: to observe the clinical effect of mesalazine combined with suppository in the treatment of radiation proctitis. Methods: from September 2014 to January 2017, the patients who were admitted to the first Hospital of Shanxi Medical University and received radiation therapy for abdominal and pelvic tumors were collected. All patients were treated with mesalazine enteric-coated tablets 1 g of Tido Poe and 0.5 g QD of mesalazine suppository for a total treatment course of 5 weeks. The total effective rate, symptom score, quality of life and blood picture before and after treatment were observed, and the injury of intestinal mucosa under endoscope was evaluated, and adverse drug reactions were recorded at the same time. Results in the treatment of radioactive proctitis, 25 cases were cured, 65 were effective, 10 were ineffective, and the total effective rate was 90. 2. After treatment, the patients had hematochezia. The number of stool increased and the integral symptom score of the physician's overall evaluation of symptoms improved significantly than before and after treatment, and the abdominal pain, acute and severe abdominal pain, and fever caused by inflammation were significantly improved before and after treatment. The difference was not significant (P 0.05). The KPS score and PLT value after treatment were significantly higher than those before treatment. The mucosal injury under colonoscopy was obviously alleviated after treatment, and the difference was statistically significant (P 0.01). There was no significant adverse reaction during the whole observation period. Conclusion: the treatment of radioactive proctitis with oral mesalazine combined with suppository can improve the clinical symptoms and quality of life, especially for the increase of stool frequency and hematochezia, and has a good safety.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R730.55

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