本文選題：胰腺癌 + 惡性生物學行為��； 參考：《中國現代醫(yī)學雜志》2015年28期

【摘要】：目的分析5野調強放療和7野調強放療的劑量學指標比較及對胰腺癌惡性生物學行為的影響。方法選擇在該院接受放療的胰腺癌患者作為研究對象,隨機分為接受5野調強放療的對照組、接受7野調強放療的觀察組,比較兩組患者的靶區(qū)及正常組織劑量分布、血清血管內皮生長因子(VEGF)及成纖維細胞生長因子(FGF)水平、血清基質金屬蛋白酶(MMP)水平等差異。結果計劃靶區(qū)(PTV)V110%區(qū)、肝臟D1/3、Dmean區(qū)、右側腎臟D1/3 7-filed IMRT低于5-filed IMRT;脊髓Dmax、左側腎臟D1/2、右側腎臟D1/37-filed IMRT高于5-filed IMRT(P0.05)。觀察組患者接受放療后的血清VEGF、α-FGF和b FGF水平均明顯低于對照組患者(P0.05)。觀察組患者接受放療后的血清MMP-2和MMP-9水平均明顯低于對照組(P0.05)。結論 7野調強放療對于胰腺癌放療具有放射物理優(yōu)勢,可以有效降低血清VEGF、FGF和MMP等水平,降低胰腺癌惡性生物學行為。
[Abstract]:Objective to compare the dosimetric indexes of 5 field intensity modulated radiotherapy (IMRT) and 7 field intensity modulated radiotherapy (IMRT) and their effects on malignant biological behavior of pancreatic cancer. Methods Pancreatic cancer patients who received radiotherapy in our hospital were randomly divided into two groups: the control group treated with 5 field intensity modulated radiation and the observation group treated with 7 field intensity modulated radiation. The dose distribution of target area and normal tissue were compared between the two groups. The serum levels of VEGF, FGFand MMPs were different. Results the planned target area was V110%, and the D1 / 3 7-filed IMRT of the right kidney was lower than that of the 5-filed, and the D1/37-filed IMRT of the right kidney was higher than that of the 5-filed IMRT P0.05, and the Dmax of the spinal cord was higher than that of the left kidney (D1 / 2), and the D1/37-filed IMRT of the right kidney was higher than that of the 5-filed IMRT (P 0.05). The serum levels of VEGF, 偽 -FGF and b FGF in the observation group were significantly lower than those in the control group (P 0.05). The levels of serum MMP-2 and MMP-9 in the observation group were significantly lower than those in the control group after radiotherapy (P 0.05). Conclusion the 7-field intensity modulated radiation therapy has the advantage of radiophysics for radiotherapy of pancreatic cancer. It can effectively reduce the levels of VEGF and MMP in serum and decrease the malignant biological behavior of pancreatic cancer.
【作者單位】： 成都363醫(yī)院體部伽瑪刀治療室;
【分類號】：R735.9;R730.55

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本文編號：1835469