本文選題：蒙特卡羅方法 + 粒子輸運(yùn)�。� 參考：《強(qiáng)激光與粒子束》2017年12期

【摘要】：提出一種基于磁場調(diào)制的質(zhì)子放射治療新方法,探索腫瘤劑量、正常器官劑量與磁場調(diào)制方法之間的關(guān)聯(lián)機(jī)制,研究磁場調(diào)制質(zhì)子放療在器官環(huán)繞型腫瘤(腫瘤被正常器官環(huán)繞或包圍)治療中的應(yīng)用�；诿商乜_粒子輸運(yùn)程序Geant4,分別建立了理想器官環(huán)繞結(jié)構(gòu)(由若干平行六面體結(jié)構(gòu)組成)和含胰腺腫瘤人體腹部解剖結(jié)構(gòu)兩種幾何構(gòu)型。分別對兩種幾何構(gòu)型內(nèi)部施加磁場,通過改變磁場強(qiáng)度和方向,調(diào)制質(zhì)子束布拉格峰幾何位置,利用質(zhì)子徑跡的磁致偏轉(zhuǎn)效應(yīng)使質(zhì)子束繞開正常器官對腫瘤進(jìn)行照射。對于理想器官環(huán)繞型構(gòu)型,磁場調(diào)制質(zhì)子放療可在保證95%劑量覆蓋腫瘤情況下將受質(zhì)子照射正常器官體積控制在接近于零的極低水平。對于胰腺腫瘤解剖構(gòu)型,磁場調(diào)制方法可使質(zhì)子束在調(diào)制磁場作用下,繞過脊髓和腎臟照射腫瘤,并使腫瘤被95%劑量較好地覆蓋。通過磁場調(diào)制,可對質(zhì)子束布拉格峰幾何位置和質(zhì)子徑跡彎曲程度進(jìn)行調(diào)制,繞過正常器官對腫瘤進(jìn)行照射,從而最大限度地減少正常器官的受照體積和劑量。
[Abstract]:A new method of proton radiation therapy based on magnetic field modulation is proposed to explore the mechanism of correlation between tumor dose, normal organ dose and magnetic field modulation. To study the application of magnetic field modulated proton radiotherapy in the treatment of organ surrounding tumor (tumor surrounded or surrounded by normal organ). Based on Monte Carlo particle transport program Geant4, two geometries, ideal organ encircling structure (composed of several parallel hexahedron structures) and human abdominal anatomic structure with pancreatic tumor, were established. By changing the intensity and direction of the magnetic field and modulating the geometric position of the proton beam Bragg peak, the proton beam can be irradiated by the magnetic deflection effect of the proton track around the normal organs. For ideal organ encircling configuration, magnetic field modulated proton radiotherapy can control the normal organ volume of protonic irradiation to close to zero when 95% dose is guaranteed to cover the tumor. For the anatomical configuration of pancreatic tumors, the magnetic field modulation method can make the proton beam bypass the spinal cord and kidney to irradiate the tumor under the action of modulated magnetic field, and make the tumor better covered by 95% dose. The geometric position of the Bragg peak of the proton beam and the degree of curve of the proton track can be modulated by the magnetic field modulation, and the tumor can be irradiated by bypassing the normal organ, thus minimizing the radiation volume and dose of the normal organ.
【作者單位】： 南京航空航天大學(xué)核科學(xué)與工程系;哈爾濱醫(yī)科大學(xué)附屬腫瘤醫(yī)院放射物理科;
【基金】：國家自然科學(xué)基金項(xiàng)目(11475087)
【分類號】：R730.55
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本文編號：1808357