本文選題：明日葉查爾酮 + 過度訓(xùn)練　； 參考：《食品科學(xué)》2017年09期

【摘要】：目的:研究明日葉查爾酮增強(qiáng)過度訓(xùn)練小鼠的免疫力及抗疲勞的能力。方法:建立雄性ICR小鼠8周跑臺的過度訓(xùn)練模型,將模型小鼠分為4個免疫大組(共200只,每大組n=50),每個免疫大組又分為低、中、高3個劑量組(160、320、800 mg/kg)、過度訓(xùn)練組及陽性對照組(紅景天西洋參膠囊200 mg/kg)(n=10),各劑量組以不同劑量的明日葉查爾酮灌胃并分別與過度訓(xùn)練組和陽性對照組進(jìn)行比較,評價過度訓(xùn)練小鼠抗疲勞能力相關(guān)指標(biāo);并通過體液免疫、細(xì)胞免疫、單核巨噬細(xì)胞功能和自然殺傷細(xì)胞水平評價其免疫能力。結(jié)果:與過度訓(xùn)練組比較;明日查爾酮中、高劑量組的肌、肝糖原含量顯著升高(P0.05),血尿素氮含量、血清乳酸脫氫酶活力、血清肌酸激酶含量顯著降低(P0.05),并與陽性對照組沒有顯著差異;中、高劑量明日葉查爾酮能夠提高自然殺傷細(xì)胞水平,促進(jìn)小鼠抗體形成細(xì)胞增殖,促進(jìn)脾淋巴細(xì)胞增殖轉(zhuǎn)化。結(jié)論:明日葉查爾酮具有較好緩解運(yùn)動性疲勞、增強(qiáng)免疫力的作用。
[Abstract]:Aim: to study the ability of Yicalcone to enhance the immunity and anti-fatigue of over-trained mice. Methods: the overtraining model of male ICR mice for 8 weeks was established. The model mice were divided into four immunized groups (200 rats, each large group with nonglutyl), and each immunized large group was divided into low and middle groups. Three high dose groups, 160320,800 mg / kg, overtraining group and positive control group (200 mg 路kg ~ (-1) 路kg ~ (-1) 路kg ~ (-1)) of Rhodiola American ginseng capsule, were perfused with different doses of Chalcone by stomach and compared with overtraining group and positive control group, respectively. The relative indexes of anti-fatigue ability of overtrained mice were evaluated, and the immune ability was evaluated by humoral immunity, cellular immunity, mononuclear macrophage function and natural killer cell level. Results: compared with overtraining group, the content of liver glycogen, blood urea nitrogen and serum lactate dehydrogenase activity in high dose group were significantly higher than those in overtraining group. The content of creatine kinase in serum decreased significantly (P 0.05), and there was no significant difference compared with the positive control group, and high dose of tomorrow leaf chalcone could increase the level of natural killer cells, promote the proliferation of antibody forming cells in mice and promote the proliferation and transformation of spleen lymphocytes. Conclusion: Chalcone can relieve exercise fatigue and enhance immunity.
【作者單位】： 唐山師范學(xué)院體育系;
【基金】：唐山市應(yīng)用基礎(chǔ)研究計劃項(xiàng)目(1413025B) 國家自然科學(xué)基金青年科學(xué)基金項(xiàng)目(31501586) 河北省自然科學(xué)基金資助項(xiàng)目(C2015209288)
【分類號】：R87
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本文編號：1780617