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CT聯(lián)合血清腫瘤標(biāo)記物在鑒別卵巢交界性腫瘤和良性上皮性腫瘤中的應(yīng)用

發(fā)布時(shí)間:2018-04-20 18:52

  本文選題:卵巢腫瘤 + 體層攝影術(shù); 參考:《重慶醫(yī)學(xué)》2017年25期


【摘要】:目的探討CT聯(lián)合血清腫瘤標(biāo)記物在卵巢交界性腫瘤(BOT)和卵巢良性上皮性腫瘤(BET)中的鑒別診斷價(jià)值。方法回顧性分析經(jīng)手術(shù)和病理證實(shí)的28例BOT和41例BET患者的CT資料,收集術(shù)前血清糖類(lèi)抗原-125(CA125)、人附睪分泌蛋白4(HE4)、癌胚抗原(CEA)的檢測(cè)結(jié)果,比較兩組腫瘤的CT影像特點(diǎn)和血清腫瘤標(biāo)記物的水平。結(jié)果兩種腫瘤實(shí)性成分、厚分隔、壁結(jié)節(jié)的出現(xiàn)率差異有統(tǒng)計(jì)學(xué)意義(χ~2=25.135、5.240、5.066,P0.05);血清CA125水平的差異有統(tǒng)計(jì)學(xué)意義(Z=3.202,P0.05),但血清HE4、CEA水平的差異無(wú)統(tǒng)計(jì)學(xué)意義(Z=0.330、1.122,P0.05);血清CA125水平鑒別兩種腫瘤的最佳臨界值、敏感性、特異性分別為42.45U/mL、53.6%、85.4%;實(shí)性成分、厚分隔診斷兩種腫瘤的總確診率為78.5%;實(shí)性成分、厚分隔、血清CA125水平診斷兩種腫瘤的總確診率為81.2%。結(jié)論卵巢上皮性腫瘤出現(xiàn)實(shí)性成分、厚分隔及血清CA125水平升高有助于鑒別BOT和BET。
[Abstract]:Objective to evaluate the value of CT combined with serum tumor markers in the differential diagnosis of ovarian borderline tumor (BOT) and benign epithelial ovarian tumor (BET). Methods CT data of 28 cases of BOT and 41 cases of BET confirmed by operation and pathology were analyzed retrospectively. The results of preoperative detection of serum carbohydrate antigen (-125), human epididymal secretory protein (HEC) and carcinoembryonic antigen (CEA) were collected. Ct features and serum tumor markers were compared between the two groups. Results the solid components of the two tumors were thickly separated. There were significant differences in the occurrence rate of mural nodules (蠂 ~ (2 / 2) 25.135n 5.240 ~ 5.066N P0.05), and the difference of serum CA125 level was statistically significant (P < 0.05), but there was no significant difference in serum HE4 ~ (1 +) CEA level (P = 0.3301.122P0.05). The serum CA125 level was the best critical value, sensitivity, and sensitivity for the identification of two kinds of tumors. The specificity was 42.45 U / mL 53.6 and 85.4, the total diagnostic rate of solid components, thick separation and serum CA125 was 78.5, and that of solid components, thick septum and serum CA125 was 81.2 and 81.2, respectively. Conclusion the presence of realistic components, thick septum and elevated serum CA125 levels in epithelial ovarian neoplasms may be helpful in differentiating BOT from BETs.
【作者單位】: 重慶醫(yī)科大學(xué)附屬第二醫(yī)院放射科;
【基金】:國(guó)家臨床重點(diǎn)專(zhuān)科建設(shè)項(xiàng)目(國(guó)衛(wèi)辦醫(yī)函[2013]544號(hào))
【分類(lèi)號(hào)】:R730.44;R737.31

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