發(fā)布時(shí)間：2018-04-05 01:16

  本文選題：ω-PUFAs　切入點(diǎn)：心肌細(xì)胞　出處：《中國(guó)油脂》2017年08期

【摘要】：探討了ω-3PUFAs對(duì)大鼠心肌細(xì)胞代謝及血清T-SOD、MDA、血乳酸、LDH、IL-4、IL-6、INF-γ干預(yù)作用。將SD大鼠分為安靜對(duì)照(Rc)組、運(yùn)動(dòng)對(duì)照(Mc)組、低劑量ω-3PUFAs灌胃(G1)組、中劑量ω-3PUFAs灌胃(G2)組和高劑量ω-PUFAs灌胃(G3)組。對(duì)SD大鼠進(jìn)行8周遞增負(fù)荷跑臺(tái)運(yùn)動(dòng)復(fù)合ω-3PUFAs干預(yù)實(shí)驗(yàn)。結(jié)果表明:實(shí)驗(yàn)組大鼠心肌細(xì)胞高能磷酸化合物含量高于Mc組;實(shí)驗(yàn)組血清T-SOD活力呈現(xiàn)上升趨勢(shì);實(shí)驗(yàn)組MDA含量呈現(xiàn)下降趨勢(shì),G1組與Mc組比較具有顯著差異(P0.05),G2、G3組與Mc組比較具有極顯著差異(P0.01);實(shí)驗(yàn)組血乳酸水平呈現(xiàn)下降趨勢(shì),G1、G2組與Mc組比較具有顯著差異(P0.05),G3組與Mc組比較具有極顯著差異(P0.01);實(shí)驗(yàn)組LDH含量呈現(xiàn)上升現(xiàn)象,且LDH含量與ω-3PUFAs劑量呈正相關(guān);實(shí)驗(yàn)組大鼠血清IL-4、IL-6、INF-γ水平低于Mc組。不同劑量ω-3PUFAs對(duì)大鼠心肌細(xì)胞代謝、抗氧化能力及血清IL-4、IL-6、INF-γ具有干預(yù)作用。
[Abstract]:The effects of 蠅 -3PUFAs on the metabolism of rat cardiomyocytes and the effects of serum T-SOD MDAand serum lactate LDH4 IL-4 IL-6 INF- 緯 were studied.Sprague-Dawley rats were divided into three groups: the rest control group (Rc), the exercise control group (McC), the low dose 蠅 -3PUFAs gavage group (G1), the middle dose 蠅 -3PUFAs group (G2) and the high dose 蠅 -PUFAs group (G3).The 8 week incremental load treadmill combined with 蠅-3 PUFAs was performed in SD rats.The results showed that the content of high energy phosphates in cardiac myocytes of experimental group was higher than that of Mc group, and the activity of serum T-SOD in experimental group showed an increasing trend.There is a significant difference in MDA content between G1 group and Mc group. There is a very significant difference between G2G3 group and Mc group, and there is a significant difference in blood lactic acid level between G1 group and Mc group in the experimental group. There are significant differences between group G3 and Mc group in blood lactic acid level of G1 group and Mc group (P 0. 05%, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05, P 0. 05).There was a significant difference in Mc group (P 0.01), and the LDH content in the experimental group was increased.The concentration of LDH was positively correlated with the dose of 蠅 -3PUFAs, and the level of IL-4 and IL-6INF- 緯 in serum of experimental group was lower than that of Mc group.Different doses of 蠅 -3PUFAs could interfere with the metabolism, antioxidant capacity and serum IL-4 / IL-6INF- 緯 of rat cardiomyocytes.
【作者單位】： 新疆師范大學(xué)體育學(xué)院運(yùn)動(dòng)生物化學(xué)實(shí)驗(yàn)室;濟(jì)南艾迪康醫(yī)學(xué)檢驗(yàn)中心;山東中醫(yī)藥大學(xué)基礎(chǔ)醫(yī)學(xué)院;
【基金】：國(guó)家自然科學(xué)基金(31660736) 2016年新疆維吾爾自治區(qū)研究生科研創(chuàng)新項(xiàng)目(XJGRI2016106)
【分類號(hào)】：R87

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