本文選題：慢性阻塞性肺疾病　切入點：CT　出處：《中國中西醫(yī)結合影像學雜志》2016年04期

【摘要】：目的 :采用CT肺功能檢查探討慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)肺氣腫表型患者的臨床特征。方法:選取2014年1月至2015年12月在我院就診的穩(wěn)定期COPD患者66例。行CT肺功能檢查,計算深吸氣末低衰減區(qū)(low attenuation area,LAA)占全肺體積百分比,即肺氣腫指數(shù)(LAA%),LAA%≥15%者為肺氣腫表型組,LAA%15%者為非肺氣腫表型組。采用慢性阻塞性肺病評價量表(CAT)評價生活質量,記錄既往急性加重次數(shù);行常規(guī)肺功能檢查記錄1 s用力呼氣容積(FEV1)、用力肺活量(FVC)、FEV1/FVC、RV/TLC;采用Pearson線性相關性分析檢驗各項指標之間的相關性。結果:66例平均CAT評分(14.83±7.56)分,平均COPD急性加重次數(shù)(2.14±1.42)次,平均FEV1(44.94±21.61)%,平均LAA%(15.25±10.52)%。LAA%與FEV1、FEV1/FVC呈負相關(r=-0.473,-0.469;P0.05),與RV/TLC、CAT評分、急性加重次數(shù)呈正相關(r=0.512,0.483,0.421;P0.05);肺氣腫表型組和非肺氣腫表型組患者在年齡、CAT評分、急性加重頻率、氣流受限方面差異均有統(tǒng)計學意義(均P0.05)。結論:LAA%與常規(guī)肺功能指標存在明顯相關性,對無法配合常規(guī)肺功能檢查者能提供較為客觀的臨床參考依據(jù);COPD肺氣腫表型患者在年齡、急性加重頻率、氣流阻力、影像學表現(xiàn)及生活質量方面具有其獨特性。
[Abstract]:Objective: to investigate the clinical features of pulmonary emphysema phenotype in patients with chronic obstructive pulmonary disease (pulmonary) by CT pulmonary function examination.Methods: 66 stable COPD patients from January 2014 to December 2015 were selected.The lung function was examined by CT, and the percentage of the volume of the whole lung in the low attenuation area of deep inspiratory attenuation were calculated, that is, the emphysema index (LAA% 鈮，

本文編號：1705700