本文選題：失重　切入點(diǎn)：藥動學(xué)　出處：《沈陽藥科大學(xué)學(xué)報》2017年05期

【摘要】：目的近年來我國載人航天事業(yè)發(fā)展迅速,載人航天飛行實(shí)踐次數(shù)逐漸增加,極大地推動了航天醫(yī)學(xué)的發(fā)展。失重是航天員飛行過程中無法擺脫的不利因素,可以引起機(jī)體廣泛的生理變化,如體液頭向分布、血容量變化、胃腸道功能紊亂等,這些改變或可引起藥物在機(jī)體內(nèi)的藥物動力學(xué)變化,進(jìn)而影響藥物的療效或產(chǎn)生毒性。目前美國航天局的航天用藥仍以地面用藥規(guī)律為指導(dǎo),這或會導(dǎo)致航天員用藥不安全問題。國內(nèi)外微重力條件下藥動學(xué)的研究較為少見,且由于實(shí)際飛行次數(shù)的限制,相關(guān)研究大多通過地面模擬實(shí)驗(yàn)來實(shí)現(xiàn)。方法結(jié)合國內(nèi)外失重藥物動力學(xué)的研究進(jìn)展以及本課題組的相關(guān)研究,圍繞吸收、分布、代謝、排泄四個過程進(jìn)行綜述。結(jié)果與結(jié)論總結(jié)了失重條件下藥動學(xué)過程的改變規(guī)律,以期為載人航天中的藥物應(yīng)用提供更多基礎(chǔ)知識和實(shí)驗(yàn)數(shù)據(jù)。
[Abstract]:Objective in recent years, China's manned space program has developed rapidly and the number of manned space flight practice has increased gradually, which has greatly promoted the development of space medicine. Weightlessness is an unfavorable factor that astronauts cannot get rid of in the course of flight. May cause a wide range of physiological changes in the body, such as head distribution of body fluids, changes in blood volume, gastrointestinal dysfunction, and so on, which may cause changes in the pharmacokinetics of drugs in the body. At present, NASA's space drugs are still guided by the law of drug use on the ground, which may lead to unsafe use of drugs by astronauts. Pharmacokinetics studies under microgravity conditions at home and abroad are relatively rare. Due to the limitation of actual flight times, most of the related studies are carried out through ground simulation experiments. Methods combined with the domestic and foreign research progress of weightlessness pharmacokinetics and the related research of our group, it revolves around absorption, distribution and metabolism. Results and conclusions the changes of pharmacokinetic process under weightlessness were summarized in order to provide more basic knowledge and experimental data for the application of drugs in manned spaceflight.
【作者單位】： 北京理工大學(xué)生命學(xué)院;中國中醫(yī)科學(xué)院中藥研究所;中國航天員科研訓(xùn)練中心;
【基金】：國家自然科學(xué)基金資助項(xiàng)目(81573693) 國家重大儀器專項(xiàng)資助項(xiàng)目(2012YQ12004410,2012YQ04014010) 1226重大資助項(xiàng)目(AWS16J018)
【分類號】：R859

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