本文選題：冠狀動(dòng)脈　切入點(diǎn)：流固耦合　出處：《中國(guó)生物醫(yī)學(xué)工程學(xué)報(bào)》2016年04期 　論文類(lèi)型：期刊論文

【摘要】：探討基于個(gè)體化患者計(jì)算機(jī)斷層血管造影(CTA)影像的冠狀動(dòng)脈流固耦合(FSI)數(shù)值分析中,不同出口邊界條件和血管壁模型對(duì)時(shí)間平均壁面剪切力(TAWSS)和馮米塞斯應(yīng)力(VMS)的影響。根據(jù)患者CTA影像重建右冠狀動(dòng)脈(RCA)管腔流域三維幾何;將管腔流域表面向外擴(kuò)張0.5 mm,形成均勻厚度血管壁;運(yùn)用類(lèi)似虛擬去除斑塊的方法建立不均勻厚度血管壁模型。FSI分析時(shí),分別給予zero和impedance兩種出口邊界條件;獲得從舒張末期開(kāi)始心動(dòng)周期主要時(shí)間點(diǎn)TAWSS和VMS的分布,比較不同模型結(jié)果的差異。結(jié)果表明,兩種出口邊界條件下,TAWSS空間分布基本一致,且血管狹窄段均高于其他部位;zero條件下峰值VMS出現(xiàn)在壓強(qiáng)最大時(shí)刻點(diǎn)0.42 s,而impedance條件下峰值VMS出現(xiàn)在入口血流速度最大時(shí)刻點(diǎn)0.64 s,并且達(dá)到前者的20倍。同是impedance出口邊界條件時(shí),TAWSS分布基本一致,沒(méi)有顯著性差異;兩種血管壁模型中,VMS的分布一致,血管狹窄段比其他部位低,但是不均勻厚度血管壁模型中局部位置VMS絕對(duì)值高于均勻壁厚血管壁模型。醫(yī)學(xué)影像技術(shù)的發(fā)展可以提供更高精度的冠脈結(jié)構(gòu)以及出入口速度和壓強(qiáng)邊界條件,不但對(duì)研究血流動(dòng)力學(xué)以及結(jié)構(gòu)力學(xué)因素與心血管疾病的關(guān)系具有重要意義,也可以更好的服務(wù)于患者個(gè)體化診斷與治療。
[Abstract]:To investigate the numerical analysis of FSIs based on computed tomography angiography (CTAA) images of individual patients with coronary artery flow and solid coupling (FSI). The effects of different outlet boundary conditions and vascular wall models on time-averaged wall shear stress (TAWSS) and von Mises stress (VMS) were studied. Three-dimensional geometry of the lumen of right coronary artery was reconstructed by CTA images. The vascular wall with uniform thickness was formed by extending the surface of the vessel basin to 0.5 mm, and the non-uniform thickness vascular wall model was established by using the method of virtual plaque removal. The zero and impedance were given two exit boundary conditions, respectively. The distributions of TAWSS and VMS at the main time points of cardiac cycle starting from the end of diastole were obtained, and the differences between the results of different models were compared. The results showed that the spatial distribution of TAWSS was basically the same under the two exit boundary conditions. The peak VMS appeared at the maximum pressure point of 0.42 s under the condition of impedance, and the peak VMS appeared at the point of the maximum flow velocity at the inlet point of 0.64 s on the impedance condition, and reached 20 times of the former, which was 20 times of that of the former. The distribution of TAWSS is basically the same at the mouth boundary condition. There was no significant difference in the distribution of VMS between the two vessel wall models. However, the absolute value of VMS in the uneven thickness vascular wall model is higher than that in the uniform wall wall model. The development of medical imaging technology can provide more accurate coronary artery structure, inlet velocity and pressure boundary conditions. Not only is it important to study the relationship between hemodynamics, structural mechanics and cardiovascular disease, but also can serve the individual diagnosis and treatment of patients better.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京安貞醫(yī)院;北京市心肺血管疾病研究所;
【基金】：首都醫(yī)學(xué)發(fā)展科研基金(2011-1005-02)
【分類(lèi)號(hào)】：R816.2
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本文編號(hào)：1619063