本文選題：喉癌　切入點：CT灌注參數(shù)　出處：《中華全科醫(yī)學》2016年03期 　論文類型：期刊論文

【摘要】：目的探討喉癌CT灌注參數(shù)與血管內(nèi)皮生長因子(VEGF)表達的相關(guān)性及其在喉癌臨床診治中的應(yīng)用價值。方法選取經(jīng)臨床活檢證實的喉癌病例23例,行術(shù)前CT灌注檢查并計算各灌注參數(shù)(BF、BV、MTT、PS)值,術(shù)后取病變組織行病理學檢查證實并行免疫組化染色,檢測其VEGF積分。應(yīng)用SPSS 13.0統(tǒng)計軟件包分別對喉癌組織和正常肌肉組CT灌注參數(shù)以及喉癌組織CT灌注參數(shù)和喉癌術(shù)后組織血管內(nèi)皮生長因子積分進行統(tǒng)計學處理,統(tǒng)計分析各CT灌注參數(shù)值與VEGF積分的相關(guān)性。結(jié)果喉癌組織和相應(yīng)區(qū)域正常肌肉間各灌注參數(shù)BF值、BV值、MTT值及PS值均存在顯著性差異,喉癌的灌注參數(shù)明顯高于正常肌肉(P0.05)。喉癌的灌注參數(shù)的BF值和BV值與其VEGF積分呈正相關(guān)(r=0.502,0.327,P0.05),MTT值與其VEGF積分呈負相關(guān)(r=-0.511,P0.05),而PS值與其VEGF積分無相關(guān)性(r=0.275,P0.05)。結(jié)論喉癌CT灌注參數(shù)BV、BF值與其VEGF積分具有明顯的相關(guān)性,可以在一定程度上反映腫瘤的血供情況,術(shù)前通過CT灌注成像觀察其參數(shù)值可以明顯提高術(shù)前喉癌檢查的準確性以及對指導(dǎo)臨床抗腫瘤血管生成治療有重要的意義,具有較高的臨床應(yīng)用價值。
[Abstract]:Objective to investigate the correlation between CT perfusion parameters and expression of vascular endothelial growth factor (VEGF) in laryngeal carcinoma and its value in diagnosis and treatment of laryngeal carcinoma. Methods 23 cases of laryngeal carcinoma confirmed by clinical biopsy were selected. Preoperative CT perfusion examination was performed, and the values of BFV BV MTT PSV were calculated. Pathological examination and immunohistochemical staining were performed on the pathological tissues after operation. The VEGF score was measured. The CT perfusion parameters of laryngeal carcinoma tissue and normal muscle group, the CT perfusion parameters of laryngeal carcinoma tissue and vascular endothelial growth factor score after laryngeal cancer operation were statistically analyzed by SPSS 13.0 statistical software package. Results there were significant differences in BF value and BV value and PS value between laryngeal carcinoma tissues and normal muscles. The perfusion parameters of laryngeal carcinoma were significantly higher than that of normal muscle carcinoma P0.05.The BF and BV values of laryngeal carcinoma were positively correlated with their VEGF scores. There was a negative correlation between VEGF value and VEGF score, but there was no correlation between PS value and VEGF score. Conclusion CT perfusion of laryngeal carcinoma has no correlation with VEGF score. There is a significant correlation between the VEGF integral and the BF value of the parameter. It can reflect the blood supply of the tumor to a certain extent. Observing the parameters by CT perfusion imaging before operation can obviously improve the accuracy of preoperative examination of laryngeal carcinoma and have important significance in guiding clinical anti-tumor angiogenesis therapy. It has high clinical application value.
【作者單位】： 杭州師范大學附屬醫(yī)院影像科;杭州師范大學附屬醫(yī)院耳鼻咽喉科;杭州師范大學附屬醫(yī)院病理科;浙江大學醫(yī)學院附屬邵逸夫醫(yī)院放射科;
【基金】：浙江省自然科學基金項目(Y2100578) 浙江省醫(yī)藥衛(wèi)生一般研究計劃項目(2011KYB068) 浙江省醫(yī)學會臨床科研基金項目(2011ZYC-A33) 杭州市衛(wèi)生科技計劃一般(A)類項目(2011A018)
【分類號】：R739.65;R730.44
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本文編號：1557138