本文關(guān)鍵詞：復(fù)方谷氨酰胺對(duì)重度放射性直腸炎的療效及對(duì)炎性細(xì)胞因子水平的影響　出處：《臨床消化病雜志》2016年01期 　論文類型：期刊論文

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【摘要】：[目的]探討復(fù)方谷氨酰胺對(duì)重度放射性直腸炎的治療效果及對(duì)患者炎性細(xì)胞因子水平的影響。[方法]78例重度放射性直腸炎患者隨機(jī)分為觀察組(41例)和對(duì)照組(37例)。對(duì)照組采用5mg地塞米松加100mg利多卡因配100ml的0.9%氯化鈉溶液每晚灌腸1次;觀察組在對(duì)照組基礎(chǔ)上加用復(fù)方谷氨酰胺口服,3次/d,每次3粒。治療3周后評(píng)價(jià)2組療效及血液中炎性細(xì)胞因子(TNF-α及IL-8)的變化。[結(jié)果]觀察組臨床有效率為78.0%(32/41),結(jié)腸鏡檢查緩解率為82.9%(34/41);對(duì)照組臨床有效率為48.6%(18/37),結(jié)腸鏡檢查緩解率為56.8%(21/37);2組在臨床有效率及結(jié)腸鏡檢查緩解率上比較均差異有統(tǒng)計(jì)學(xué)意義(P0.05)。治療后2組血液中TNF-α及IL-8均下降,但觀察組較對(duì)照組下降更明顯(P0.05)。[結(jié)論]在用地塞米松加利多卡因灌腸治療重度放射性直腸炎的基礎(chǔ)上加用復(fù)方谷氨酰胺口服,可以顯著提高臨床有效率及結(jié)腸鏡檢查緩解率,并能顯著降低血液中炎性細(xì)胞因子的水平。
[Abstract]:[Objective] to explore the therapeutic effect of Compound Glutamine on severe radiation proctitis and effects on cytokine levels in patients with osteoarthritis. Methods]78 cases of severe radiation proctitis patients were randomly divided into observation group (41 cases) and control group (37 cases). The control group was treated with 5mg dexamethasone plus 100mg lidocaine and 100ml 0.9% Sodium Chloride Solution for 1 times per night. The observation group was given compound glutamine orally, 3 times /d and 3 capsules each time on the basis of the control group. After 3 weeks of treatment, the effects of the 2 groups and the changes of inflammatory cytokines (TNF- alpha and IL-8) in the blood were evaluated. [results] the clinical effective rate of observation group was 78% (32/41), the remission rate of colonoscopy was 82.9% (34/41); the control group clinical effective rate was 48.6% (18/37), the remission rate of colonoscopy was 56.8% (21/37); the 2 groups in the clinical efficiency of colonoscopy and the remission rate is significantly difference between statistical significance (P0.05). After treatment, the blood TNF- alpha and IL-8 decreased in the 2 groups, but the decrease in the observation group was more obvious than that in the control group (P0.05). [Conclusion] in treatment with dexamethasone and lidocaine based enema in the treatment of radiation proctitis severe combined with compound glutamine orally, can the clinical efficiency of colonoscopy and the remission rate was significantly increased, and can decrease the inflammatory cytokine levels in the blood.
【作者單位】： 解放軍309醫(yī)院消化科;
【分類號(hào)】：R730.55
【正文快照】： 直腸癌、前列腺癌、宮頸癌、卵巢癌等盆腔內(nèi)腫支持的腹瀉或需衛(wèi)生紙輔助才可排出的便血、腹脹瘤放射治療后常見并發(fā)癥為放射性直腸炎[1]。臨床(X線平片證實(shí)腸管擴(kuò)張);Ⅳ級(jí):急性或亞急性腸梗主要表現(xiàn)為腹痛、腹瀉、便血及里急后重,內(nèi)鏡下可阻,瘺管,穿孔和需輸血的出血、需胃腸，

本文編號(hào)：1339387