本文選題：海帶提取物 + 脾臟系數(shù)��； 參考：《食品科技》2017年09期

【摘要】：目的:考察海帶提取物對免疫力低下小鼠的影響,探討海帶提取物的免疫調(diào)節(jié)作用。方法:用環(huán)磷酰胺制備免疫力低下小鼠模型,并將昆明種小鼠隨機(jī)分為空白組、模型組、低、高劑量海帶提取物組和陽性藥物(脾氨肽)組。記錄小鼠活動量、體重變化,計算脾臟系數(shù)、胸腺系數(shù),檢測各組IL-6和TNF-α血清水平。結(jié)果:與模型組比較,海帶提取物在4.5 mg/g、13.5 mg/g劑量均可使小鼠體質(zhì)改善、體重增長;海帶提取物高劑量組的脾臟系數(shù)增高,而低劑量組的胸腺系數(shù)增高;高、低劑量組的白介素6(IL-6)均有所增高,而低劑量組的α腫瘤壞死因子(TNF-α)血清水平顯著降低。結(jié)論:海帶提取物能增強(qiáng)免疫低下小鼠的體質(zhì);同時可以提高小鼠的脾腺系數(shù)和胸腺系數(shù),顯示其在不同劑量分別調(diào)節(jié)體液免疫和細(xì)胞免疫的作用;海帶提取物降低TNF-α而升高IL-6水平意味著其具有一定的抗炎癥和調(diào)節(jié)Th1/Th2免疫平衡的作用。
[Abstract]:Objective: to investigate the effect of kelp extract on immunoregulation of immunocompromised mice. Methods: Kunming mice were randomly divided into blank group, model group, low and high dose kelp extract group and positive drug (spleen ammonia peptide) group. The changes of activity and body weight were recorded, spleen coefficient and thymus coefficient were calculated, and serum levels of IL-6 and TNF- 偽 were measured. Results: compared with the model group, kelp extract at 4.5 mg / g for 13.5 mg/g could improve the physique and increase the body weight of mice, and the spleen coefficient in the high dose group was higher than that in the low dose group, and the thymus coefficient in the low dose group was higher than that in the low dose group. The serum level of TNF-偽 in low dose group was significantly lower than that in low dose group. Conclusion: the extract of Laminaria japonica can enhance the physique of immunocompromised mice, and increase the coefficient of spleen gland and thymus gland of mice, which shows that the extracts of Laminaria japonica can regulate humoral immunity and cellular immunity in different dosages, respectively. Kelp extract decreased TNF- 偽 and increased IL-6 level, which indicated that it had anti-inflammatory effect and regulated Th1 / Th2 immune balance.
【作者單位】： 中國人民解放軍第四二一醫(yī)院皮膚科;廣州大學(xué)化學(xué)化工學(xué)院;無限極(中國)有限公司;
【基金】：廣東省省級科技計劃項目(2013B090600159) 廣州市科技計劃項目(201508020008)
【分類號】：R151

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本文編號：2105783