本文選題：鄰苯二甲酸酯(PAEs) + 二苯甲酮(BPs)型紫外吸收劑　； 參考：《哈爾濱工業(yè)大學(xué)》2016年博士論文

【摘要】：環(huán)境內(nèi)分泌干擾物(Environmental endocrine disruptors,EEDs)是一類可導(dǎo)致健康有機(jī)體內(nèi)分泌紊亂的物質(zhì)。鄰苯二甲酸酯(Phthalate Esters,PAEs)、二苯甲酮(Benzophenone,BP)型紫外吸收劑和雙酚A(Bisphenol A,BPA)是三類重要的EEDs,廣泛應(yīng)用于各類產(chǎn)品中,可通過揮發(fā)、溶解等方式釋放到環(huán)境中,并經(jīng)飲食攝入、呼吸吸入以及皮膚接觸等方式進(jìn)入人體,對人體健康產(chǎn)生不利影響。本文采集全國范圍內(nèi)109份青年人群尿液樣品,全面系統(tǒng)地分析了青年人群體內(nèi)PAEs、BP型紫外吸收劑和BPA的暴露水平,并以哈爾濱市PAEs、BP型紫外吸收劑和BPA職業(yè)暴露人群為研究對象,采集60份職業(yè)暴露人群尿液樣品,分析不同職業(yè)人群尿液中PAEs、BP型紫外吸收劑和BPA的污染特征,確定人體內(nèi)PAEs、BP型紫外吸收劑和BPA暴露的潛在來源。同時(shí),計(jì)算青年人群和哈爾濱市職業(yè)暴露人群體內(nèi)PAEs、BP型紫外吸收劑和BPA的暴露量,確定青年人群和職業(yè)暴露人群體內(nèi)PAEs、BP型紫外吸劑和BPA單一暴露風(fēng)險(xiǎn)和累積暴露風(fēng)險(xiǎn)。在此基礎(chǔ)上,以人體內(nèi)累積風(fēng)險(xiǎn)理論為基礎(chǔ),建立人體內(nèi)PAEs和BPA暴露的累積風(fēng)險(xiǎn)可靠性評估方法,評估青年人群和職業(yè)暴露人群體內(nèi)PAEs和BPA的累積風(fēng)險(xiǎn)。我國青年人群尿液中PAEs代謝物、BP型紫外吸收劑和BPA的總濃度范圍分別為71.3-2670 ng/m L、0.18-67.1 ng/m L和0.19-23.9 ng/m L,m MP、m BP、mi BP和DEHP代謝物是主要的PAEs代謝物,BP-3、BP-1和4-HBP是主要的BP型紫外吸收劑。青年人群尿液中PAEs代謝物、BP型紫外吸收劑和BPA的來源復(fù)雜,飲食攝入是DEHP代謝物和BP-8的主要來源,飲食攝入和呼吸是m CPP、m BP和mi BP的共同來源,氣態(tài)空氣是m MP、4-HBP、BP-2和BPA主要來源,個(gè)人護(hù)理品是m EP的主要來源。哈爾濱市職業(yè)暴露人群尿液中PAEs代謝物、BP型紫外吸收劑和BPA的總濃度高于哈爾濱市普通人群,職業(yè)暴露人群尿液中各種PAEs代謝物和BP型紫外吸收劑的組成特征與普通人群相比差異較大。建筑材料、油漆涂料和美發(fā)產(chǎn)品是DMP的重要來源,美發(fā)產(chǎn)品是DEP的重要來源,油漆涂料、地板材料、紡織品和美發(fā)產(chǎn)品是DBP和DIBP的重要來源,地板材料、油漆涂料和紡織品是DEHP的重要來源。建筑材料、油漆涂料和紡織品是BP-2的重要來源,建筑材料、油漆涂料、電子產(chǎn)品和地板材料是BPA的重要來源。我國青年人群體內(nèi)PAEs、BP型紫外吸收劑和BPA的暴露量計(jì)算結(jié)果表明,PAEs的暴露量占三類物質(zhì)暴露總量的99%以上。我國部分青年人群對于單一PAEs的暴露水平已超出了歐洲食品安全局(EFSA)建議的安全標(biāo)準(zhǔn),青年人群對于PAEs和BPA的累積暴露存在致病風(fēng)險(xiǎn),危險(xiǎn)指數(shù)超出安全閾值(HI1)的比例為39.8%。同時(shí),以累積風(fēng)險(xiǎn)理論為基礎(chǔ),對DBP、DIBP、DEHP4類樣本進(jìn)行了概率密度擬合,建立了人體PAEs和BPA累積暴露風(fēng)險(xiǎn)的極限狀態(tài)方程,計(jì)算了PAEs和BPA累積風(fēng)險(xiǎn)的可靠指標(biāo)和失效概率,對人體內(nèi)三種PAEs(DBP、DIBP、DEHP)和BPA暴露量的累積風(fēng)險(xiǎn)進(jìn)行可靠性評估,結(jié)果表明,青年人群體內(nèi)PAEs和BPA累積暴露風(fēng)險(xiǎn)的可靠性指標(biāo)為0.41,失效概率為34.02%,說明我國青年人群體內(nèi)PAEs和BPA的累積暴露量存在較高的致病風(fēng)險(xiǎn)。本文首次在國家尺度層面上同時(shí)分析了PAEs、BP型紫外吸收劑和BPA在人體內(nèi)的暴露情況,具有廣泛的代表性。PAEs代謝物、BP型紫外吸收劑和BPA的人體監(jiān)測研究是的人體暴露評價(jià)的重要組成部分,可為評估我國青年人群體內(nèi)此類物質(zhì)的健康風(fēng)險(xiǎn)水平和暴露控制策略提供數(shù)據(jù)支持和理論依據(jù)。同時(shí),建立基于累積風(fēng)險(xiǎn)理論的可靠性方法,評估人體內(nèi)多種污染物累積風(fēng)險(xiǎn)的可靠性,可為更加準(zhǔn)確的評估人體內(nèi)PAEs和BPA的累積致病風(fēng)險(xiǎn)提供可靠的依據(jù)。
[Abstract]:Environmental endocrine disruptors (EEDs) is a class of substances that can cause endocrine disorders in healthy organisms. Phthalate (Phthalate Esters, PAEs), two benzophenone (Benzophenone, BP) type UV Absorbents and bisphenol A (Bisphenol A) are the three important categories of products, which are widely used in various products. It was released into the environment by excessive volatilization and dissolution, and entered the human body through diet intake, breathing inhalation and skin contact. The urine samples of 109 young people throughout the country were collected, and the exposure levels of PAEs, BP type UV Absorbents and BPA in young people were systematically analyzed. The urine samples of 60 occupational exposed populations were collected from Harbin PAEs, BP UV Absorbents and BPA occupational exposure population. The contamination characteristics of PAEs, BP type UV Absorbents and BPA in urine of different occupational groups were analyzed, and the potential sources of PAEs, BP type UV Absorbents and BPA exposure in human body were determined. Meanwhile, the young people and the young people were calculated. PAEs, BP type UV Absorbents and BPA exposure in the occupational exposure population of Harbin, determine the risk and risk of single exposure and cumulative exposure of PAEs, BP type and BPA in young and occupational exposed populations. Based on this, the cumulative risk of PAEs and BPA exposure in the human body is based on the cumulative risk theory of human body, and the cumulative risk of PAEs and BPA exposure can be established. The cumulative risk of PAEs and BPA in young people and occupationally exposed populations was evaluated by sex assessment. The total concentrations of PAEs metabolites, BP type UV absorbers and BPA in the urine of young people in our country were 71.3-2670 ng/m L, 0.18-67.1 ng/m L and 0.19-23.9, respectively. BP-1 and 4-HBP are the main BP type ultraviolet absorbents. The urine of young people is PAEs metabolites, BP type ultraviolet absorbents and BPA sources are complex. Dietary intake is the main source of DEHP metabolites and BP-8. Dietary intake and respiration are the common source of M CPP, m BP and BP-8. The main source of EP. The total concentration of PAEs metabolites in urine, BP type UV Absorbents and BPA in Harbin occupational exposure population is higher than that of the common people in Harbin. The composition characteristics of various PAEs metabolites and BP type UV Absorbents in the urine of occupational exposure population are different from those of the general population. It is an important source of DMP. Hairdressing is an important source of DEP. Paints, flooring materials, textiles and hair products are important sources of DBP and DIBP. Floor materials, paints and textiles are important sources of DEHP. Building materials, paint coatings and textiles are the important sources of BP-2, construction materials, paint and coatings, electronic products and sites. Plate material is an important source of BPA. The results of PAEs, BP type UV Absorbents and BPA exposure in our young people showed that the exposure of PAEs accounted for more than 99% of the total exposure of three types of material. The exposure level of some young people to a single PAEs in our country exceeded the safety standards recommended by the European Food Safety Bureau (EFSA), young people. The cumulative exposure to PAEs and BPA has a pathogenic risk. The risk index exceeds the safety threshold (HI1) ratio 39.8%.. Based on the cumulative risk theory, the probability density fitting is carried out on the DBP, DIBP and DEHP4 samples. The limit state equation for the cumulative exposure of PAEs and BPA in human body is established, and the cumulative risk of PAEs and BPA is calculated. Reliability index and failure probability are used to evaluate the cumulative risk of three kinds of PAEs (DBP, DIBP, DEHP) and BPA exposure in the human body. The results show that the reliability index of the cumulative exposure risk of PAEs and BPA in the young people is 0.41 and the failure probability is 34.02%, which indicates that the cumulative exposure of PAEs and BPA in the young people of our country is high. It is the first time to analyze the exposure of PAEs, BP type UV Absorbents and BPA in the human body at the national scale, with extensive representative.PAEs metabolites, BP type UV Absorbents and BPA human monitoring research as an important part of human exposure evaluation, which can be used to evaluate the body of young people in our country. The health risk level of the substance and the exposure control strategy provide data support and theoretical basis. At the same time, a reliability method based on cumulative risk theory is established to assess the reliability of cumulative risk of multiple pollutants in the human body, which can provide a reliable basis for more accurate assessment of the cumulative risk of PAEs and BPA in the human body.
【學(xué)位授予單位】：哈爾濱工業(yè)大學(xué)
【學(xué)位級別】：博士
【學(xué)位授予年份】：2016
【分類號】：R114

【相似文獻(xiàn)】

相關(guān)期刊論文 前2條

1 孟輝;;三種果皮中紫外吸收劑的提取[J];遼東學(xué)院學(xué)報(bào)(自然科學(xué)版);2011年02期

2 ;[J];;年期

相關(guān)會(huì)議論文 前5條

1 李強(qiáng)林;黃方千;馮西寧;楊東潔;任建華;;紡織品中有機(jī)紫外吸收劑綜述[A];第四屆中國（廣東）紡織助劑行業(yè)年會(huì)論文集[C];2012年

2 唐方輝;;彩色熱敏紙用紫外吸收劑前體的合成及應(yīng)用[A];中國感光學(xué)會(huì)第七次全國會(huì)員代表大會(huì)暨學(xué)術(shù)年會(huì)和第七屆青年學(xué)術(shù)交流會(huì)論文摘要集[C];2006年

3 肖銘;陰俊霞;李敏;杜宇國;魏東斌;;紫外防曬劑BP-4氯化反應(yīng)研究[A];第六屆全國環(huán)境化學(xué)大會(huì)暨環(huán)境科學(xué)儀器與分析儀器展覽會(huì)摘要集[C];2011年

4 朱支薔;陳德銓;;DSC法測定藥物中間體紫外吸收劑等的純度[A];2003年藥物分析論壇“熱分析在藥物分析中的應(yīng)用”專題學(xué)術(shù)研討會(huì)論文集[C];2003年

5 唐人成;曹機(jī)良;;紫外吸收劑對竹漿纖維的吸附特點(diǎn)及防護(hù)性能[A];“浙江宏達(dá)”杯第三屆全國印染新技術(shù)暨助劑新產(chǎn)品新成果學(xué)術(shù)交流會(huì)論文集[C];2009年

相關(guān)博士學(xué)位論文 前1條

1 高崇婧;典型環(huán)境內(nèi)分泌干擾物的人體暴露及健康風(fēng)險(xiǎn)評價(jià)[D];哈爾濱工業(yè)大學(xué);2016年

相關(guān)碩士學(xué)位論文 前10條

1 唐慧;紫外吸收劑在紡織品上的吸附、解吸和應(yīng)用性能[D];蘇州大學(xué);2012年

2 徐蕾;城市污水系統(tǒng)中苯并三唑類紫外吸收劑去除特征研究[D];哈爾濱工業(yè)大學(xué);2016年

3 朱仁慶;含氟紫外吸收劑的合成及性質(zhì)研究[D];重慶大學(xué);2012年

4 岳森;棉用反應(yīng)型紫外吸收劑的制備及應(yīng)用[D];北京服裝學(xué)院;2008年

5 王永云;三嗪類紫外吸收劑的合成及工藝研究[D];南京理工大學(xué);2012年

6 沈云;新型二苯甲酮型紫外吸收劑的合成及其在棉織物上的應(yīng)用[D];江南大學(xué);2013年

7 艾文;一種新型苯并三唑類紫外吸收劑的合成[D];大連理工大學(xué);2008年

8 王天娥;微萃取技術(shù)與高效液相色譜聯(lián)用富集并測定環(huán)境水樣中的紫外吸收劑[D];西北師范大學(xué);2015年

9 祝迎花;苯并三唑類紫外吸收劑的合成工藝研究[D];南京理工大學(xué);2010年

10 姚婷婷;紫外吸收劑/LDHs改性瀝青的制備與性能研究[D];武漢理工大學(xué);2014年

，

本文編號：2093259