本文選題：硫酸銦 + 生殖毒性��； 參考：《環(huán)境與健康雜志》2017年07期

【摘要】：為探討硫酸銦對雄性大鼠的生殖毒性效應(yīng),將32只健康SPF級雄性Wistar大鼠隨機(jī)分為4組,分別為對照(生理鹽水)組和52.30、104.60、261.40 mg/kg硫酸銦染毒組,每組8只。采用灌胃方式進(jìn)行染毒,每天1次,每周5次,連續(xù)染毒8周。檢測大鼠血清睪酮(T)、黃體生成素(LH)、卵泡刺激素(FSH)濃度及附睪精子數(shù)量、精子存活率和精子畸形率。結(jié)果顯示,與對照組相比,僅261.40 mg/kg硫酸銦染毒組大鼠的睪丸、附睪重量及其臟器系數(shù)均降低,差異均有統(tǒng)計學(xué)意義(P0.05);且隨著硫酸銦染毒劑量的升高,大鼠的睪丸、附睪重量及其臟器系數(shù)均呈下降趨勢。與對照組比較,104.60、261.4 mg/kg硫酸銦染毒組大鼠的血清T水平均降低,而261.4 mg/kg硫酸銦染毒組大鼠的血清FSH水平較高,差異均有統(tǒng)計學(xué)意義(P0.05);各劑量硫酸銦染毒組大鼠的血清LH水平均無明顯變化。提示硫酸銦對雄性大鼠具有生殖毒性。
[Abstract]:To investigate the reproductive toxicity of indium sulfate on male rats, 32 healthy SPF male Wistar rats were randomly divided into four groups: the control group (normal saline) group and the 52.30104.60261.40 mg/kg indium sulfate group with 8 rats in each group. The rats were administrated by gavage once a day, 5 times a week for 8 weeks. Serum testosterone (T), luteinizing hormone (LH), follicle stimulating hormone (FSH), sperm count, sperm survival rate and sperm abnormality rate were measured. The results showed that compared with the control group, the testis weight and organ coefficient of the rats exposed to indium sulfate for 261.40 mg/kg were significantly lower than those of the control group (P0.05), and the testis of the rats increased with the increase of the dose of indium sulfate. The weight of epididymis and the organ coefficient of epididymis decreased. Compared with the control group, the serum T levels of the rats exposed to indium sulfate 104.60261.4 mg/kg were decreased, while those of the rats exposed to indium sulfate for 261.4 mg/kg were higher than those in the control group. The difference was statistically significant (P0.05); the serum LH level of rats exposed to indium sulfate had no significant change. The results suggest that indium sulfate has reproductive toxicity to male rats.
【作者單位】： 華北理工大學(xué)公共衛(wèi)生學(xué)院;
【基金】：國家衛(wèi)生計生委衛(wèi)生公益性行業(yè)科研專項(201402021) 華北理工大學(xué)大學(xué)生創(chuàng)新性實驗計劃(X2015163)
【分類號】：R114

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