發(fā)布時間：2018-06-13 06:31

  本文選題：孕婦 + -羥基維生素D　； 參考：《南京醫(yī)科大學學報(自然科學版)》2017年07期

【摘要】：目的:分析江蘇省部分孕期婦女不同季節(jié)血清維生素D水平,了解其維生素D營養(yǎng)狀況。方法:于2013年1月—2015年12月間在江蘇省8個地區(qū)不同醫(yī)院的圍產營養(yǎng)門診采集18 478名健康孕婦的空腹血樣,采用液相色譜-串聯(lián)質譜(LC-MS/MS)法測量血清25-羥基維生素D3[25(OH)D3]和25-羥基維生素D2[25(OH)D2]的濃度。25(OH)D2和25(OH)D3總和為25-羥基維生素D[25(OH)D],以25(OH)D為體內維生素D水平的指標進行統(tǒng)計分析。結果:全部18 478名孕婦的血清25(OH)D濃度平均為(19.2±9.4)ng/mL,維生素D缺乏率[25(OH)D20 ng/mL]為59.7%,嚴重缺乏率[25(OH)D12 ng/mL]為24.9%,充足率[25(OH)D30 ng/mL]為13.7%。2013、2014、2015年孕婦的平均血清25(OH)D濃度分別為(17.3±8.5)、(18.2±9.0)、(20.5±9.7)ng/mL,其維生素D缺乏率分別為69.4%、63.6%、54.4%。不同年份孕婦25(OH)D水平的差異具有統(tǒng)計學意義(P0.01)。江蘇省蘇南、蘇中、蘇北地區(qū)的孕婦血清25(OH)D濃度平均分別為(19.2±9.5)、(19.6±9.0)、(18.4±8.7)ng/mL,維生素D缺乏率分別為60.0%、57.9%、62.8%,不同地區(qū)間孕婦25(OH)D水平的差異具有統(tǒng)計學意義(P0.01)。孕婦血清25(OH)D濃度與年齡呈正相關(r=0.8,P0.01)。孕婦維生素D的水平與檢測血清25(OH)D濃度的季節(jié)有關,夏秋季高于春冬季,其血清25(OH)D濃度依次為(22.7±9.2)、(22.2±9.3)、(15.3±7.3)、(12.3±6.4)ng/mL。結論:孕婦維生素D缺乏率高,應加強對孕婦維生素D水平的監(jiān)測,及時指導維生素D缺乏的孕婦合理補充維生素D。
[Abstract]:Objective: to analyze the serum vitamin D levels of some pregnant women in Jiangsu province and to understand their vitamin D nutritional status. Methods: from January 2013 to December 2015, the fasting blood samples of 18 478 healthy pregnant women were collected from perinatal nutrition outpatient clinics in 8 hospitals in Jiangsu Province. The concentrations of 25-hydroxy-vitamin D _ 3 and 25-hydroxyvitamin D _ 2 [25 OHH _ 2 D _ 2] were measured by liquid chromatography-tandem mass spectrometry (LC-MS / MS) method. The sum of 25 OHH D _ 2 and 25 OHH _ 2 D _ 3 were 25 hydroxyvitamin D [25OHD], and 25 OHH D was used as the index of vitamin D level in vivo. Results: the average serum concentration of 25 OHHN D in all 18 478 pregnant women was 19.2 鹵9.4 ng / mL, the vitamin D deficiency rate was 59.7, the severe deficiency rate was 24.9, the filling rate was 13.7.2013ng/ mL, and the average serum concentration of 25OHHN in 2015 was 17.3 鹵8.5ng-1 / mL, respectively. The vitamin D deficiency rate was 69.4ngmL, and the vitamin D deficiency rate was 69.4ngmL, respectively. The difference of OHH D level in pregnant women in different years was statistically significant (P 0.01). The average serum concentration of 25OHHU D was 19.2 鹵9.5ng / mL in south Jiangsu, middle Jiangsu and northern Jiangsu, respectively. The vitamin D deficiency rate was 60.0% and 57.9% (P < 0.01), respectively. There was a positive correlation between the serum concentration of 25 OHH D and the age of pregnant women. The level of vitamin D in pregnant women was related to the season of detecting serum 25 OHH D, which was higher in summer and autumn than in spring and winter. The serum concentration of 25 OHH D was 22. 7 鹵9. 2 鹵9. 3 鹵9. 3 鹵9. 3 鹵7. 3 鹵6. 4 ng / mL. Conclusion: the rate of vitamin D deficiency in pregnant women is high. It is necessary to strengthen the monitoring of vitamin D level of pregnant women and guide the pregnant women with vitamin D deficiency to supplement vitamin D.
【作者單位】： 南京醫(yī)科大學公共衛(wèi)生學院兒少衛(wèi)生與婦幼保健學系;南京醫(yī)科大學公共衛(wèi)生學院衛(wèi)生檢驗系;
【基金】：江蘇高校優(yōu)勢學科建設工程資助項目
【分類號】：R153.1
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本文編號：2013063