本文選題：急性馳緩性麻痹 + 脊髓灰質(zhì)炎疫苗病毒��； 參考：《現(xiàn)代預(yù)防醫(yī)學(xué)》2015年09期

【摘要】：目的分析脊髓灰質(zhì)炎(脊灰)病毒(PV)的急性馳緩性麻痹(AFP)病例流行病學(xué)特征,為維持無脊髓灰質(zhì)炎狀態(tài)提供科學(xué)依據(jù)。方法采用描述性流行病學(xué)方法對(duì)玉林市2000-2013年檢出的PV陽性AFP病例進(jìn)行流行病學(xué)分析。結(jié)果玉林市2000-2013年共檢測(cè)了451例急性馳緩性麻痹病例的糞便標(biāo)本,檢出PV13株,檢出率2.88%,型內(nèi)特征鑒定有1株為疫苗變異PV,經(jīng)VP1基因核苷酸序列測(cè)定達(dá)到VDPV的分類標(biāo)準(zhǔn)。分離到的PV以Ⅱ型為主,AFP病例散在發(fā)生,無聚集性。未全程免疫兒童全程免疫兒童,年齡以≤1歲兒童為主(92.31%)。服苗1月內(nèi)出現(xiàn)麻痹占46.15%(6/13),麻痹伴發(fā)熱占61.54%,60 d后隨訪仍殘留麻痹病例高達(dá)23.08%,以Ⅱ型疫苗株為主。結(jié)論玉林市2000-2013年未發(fā)現(xiàn)由脊灰野病毒引起的病例。在無脊灰證實(shí)階段,存在著疫苗衍生病毒(VDPV)和發(fā)生VDPV循環(huán)(c VDPVs)的可能,保持AFP病例監(jiān)測(cè)的敏感性,加強(qiáng)對(duì)脊灰疫苗衍生病毒的監(jiān)測(cè)及研究,具有重要的現(xiàn)實(shí)意義。
[Abstract]:Objective to analyze the epidemiological characteristics of acute flaccid paralysis (AFP) of poliovirus (PVV) in order to provide scientific basis for maintaining poliomyelitis free state. Methods Epidemiological analysis of PV positive AFP cases from 2000 to 2013 was carried out in Yulin. Results A total of 451 fecal specimens of patients with acute flaccid paralysis were detected in Yulin city from 2000 to 2013. The detection rate of PV13 strain was 2.88. One strain was identified as vaccine variant by intratype characterization. The nucleotide sequence analysis of VP1 gene reached the classification standard of VDPV. The PV isolated was mainly type 鈪，

本文編號(hào)：1921812