Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α in the endoplasmic reticulum stress signaling pathway. To verify this hypothesis, we occluded the middle cerebral artery in rats to establish focal cereb... 

【文章來(lái)源】：Neural Regeneration Research. 2015年08期

【文章頁(yè)數(shù)】：6 頁(yè)

【文章目錄】：
Introduction
Materials and Methods
    Establishing cerebral ischemia/reperfusion model
    Drug administration
    TTC staining of brain infarct volume
    Transmission electron microscopy observation of the ultrastructure of the rat brain
    Western blot analysis of PERK, phosphorylated e IF2αand caspase-3 expression in rat brain tissue infarction side
    Statistical analysis
Results
    Atorvastatin decreased brain infarct volume in rats with cerebral ischemia/reperfusion injury
    Atorvastatin improved ultrastructure of brain tissue in rats with cerebral ischemia/reperfusion injury
    Atorvastatin reduced caspase-3, phosphorylated e IF2and PERK expression in infarcted brain tissue of rats with cerebral ischemia/reperfusion injury
Discussion


【參考文獻(xiàn)】：
期刊論文
[1]針刺對(duì)戊四唑誘發(fā)驚厥大鼠海馬葡萄糖調(diào)節(jié)蛋白78和C/EBP同源蛋白表達(dá)的影響[J]. 楊帆,馬允,昂文平,陳浩,杜衛(wèi)東,吳生兵,呂磊,張道芹.  針刺研究. 2014(04)



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