基于開環(huán)聚合的兩親性樹枝狀共聚物在化療方面的研究
發(fā)布時間：2019-08-03 19:09
【摘要】：基于開環(huán)聚合構(gòu)建了一種新型樹枝狀共聚物(PEG-G3-PCL)作為藥物載體,而該藥物載體是由三代樹枝狀聚酯(PEG-G3-OH)引發(fā)己內(nèi)酯(CL)開環(huán)聚合而成的。兩親性的PEG-G3-PCL能自組裝成膠束,并且對化療藥物阿霉素(DOX)擁有較高的藥物裝載能力和包封率。體外藥物釋放的研究結(jié)果表明:該膠束能快速釋放DOX,裝載DOX的PEG-G3-PCL膠束具有良好的化療效果,并且PEG-G3-PCL膠束幾乎無毒。
[Abstract]:A novel dendrimer (PEG-G3-PCL) was constructed as drug carrier based on ring-opening polymerization. The drug carrier was prepared by ring-opening polymerization of caprolactone (CL) initiated by third generation dendritic polyester (PEG-G3-OH). Amphiphilic PEG-G3-PCL can self-assemble micelle and has high drug loading ability and entrapment efficiency for doxorubicin (DOX). The results of drug release in vitro showed that the micelle could rapidly release the PEG-G3-PCL micelle loaded with DOX by DOX, and had good chemotherapy effect, and the PEG-G3-PCL micelle was almost non-toxic.
【作者單位】： 華東理工大學(xué)材料科學(xué)與工程學(xué)院;
【分類號】：R979.1
，
本文編號：2522735
[Abstract]:A novel dendrimer (PEG-G3-PCL) was constructed as drug carrier based on ring-opening polymerization. The drug carrier was prepared by ring-opening polymerization of caprolactone (CL) initiated by third generation dendritic polyester (PEG-G3-OH). Amphiphilic PEG-G3-PCL can self-assemble micelle and has high drug loading ability and entrapment efficiency for doxorubicin (DOX). The results of drug release in vitro showed that the micelle could rapidly release the PEG-G3-PCL micelle loaded with DOX by DOX, and had good chemotherapy effect, and the PEG-G3-PCL micelle was almost non-toxic.
【作者單位】： 華東理工大學(xué)材料科學(xué)與工程學(xué)院;
【分類號】：R979.1
，
本文編號：2522735
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