【摘要】：目的回顧石墨烯、碳納米管、富勒烯C60等3種碳基納米顆粒吸入毒性試驗(yàn)的過往文獻(xiàn)資料并對其理化特性、吸入毒性、機(jī)制以及國內(nèi)外研究現(xiàn)狀作一綜述,為開展有關(guān)試驗(yàn)研究提供參考。方法通過GCBI、Pubmed、萬方數(shù)據(jù)庫和中國知網(wǎng)收集過往相關(guān)文獻(xiàn)。結(jié)果碳基納米顆粒能夠經(jīng)呼吸道進(jìn)入機(jī)體,并沉積下來,引發(fā)嚴(yán)重的肺部炎癥、抑制細(xì)胞增殖、使肺清除功能下降、氧化損傷以及形成肺組織纖維化和肉芽腫等。結(jié)論碳基納米顆粒的吸入毒性和作用機(jī)制備受關(guān)注,它對呼吸系統(tǒng)的影響不容忽視,有的職業(yè)工種是碳基納米顆粒暴露的高危人群,在將納米技術(shù)大規(guī)模應(yīng)用于各個(gè)領(lǐng)域的同時(shí)也應(yīng)該注意其安全性。
[Abstract]:Objective to review the previous literature of inhalation toxicity test of graphene, carbon nanotube and fullerene C60, and to review their physical and chemical properties, inhalation toxicity, mechanism and research status at home and abroad. It provides a reference for the relevant experimental research. Methods the relevant literature was collected through GCBI,Pubmed, Wanfang Database and China knowledge Network. Results carbon-based nanoparticles could enter the body through respiratory tract and precipitate, induce serious lung inflammation, inhibit cell proliferation, decrease lung clearance function, oxidative damage and formation of pulmonary fibrosis and granuloma. Conclusion the inhalation toxicity and mechanism of carbon nanoparticles have attracted much attention, and its effect on respiratory system can not be ignored. Some occupational jobs are at high risk of exposure to carbon nanoparticles. When nanotechnology is applied to various fields on a large scale, attention should also be paid to its safety.
【作者單位】： 貴州醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;貴州省分析測試研究院;
【基金】：國家國際科技合作專項(xiàng),項(xiàng)目編號,2015DFA41280 遺傳資源與進(jìn)化國家重點(diǎn)實(shí)驗(yàn)室開放課題(GREKF17-15) 環(huán)境化學(xué)與生態(tài)毒理學(xué)國家重點(diǎn)實(shí)驗(yàn)室開放基金(KF2016-21) 中央引導(dǎo)地方科技科技發(fā)展專項(xiàng),黔科中引地[2016]4001號
【分類號】：R99
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本文編號：2496184