藥物安全性評價中乳腺毒性病理學(xué)檢查的特點(diǎn)和意義
發(fā)布時間:2019-05-28 07:57
【摘要】:正乳腺是由大汗腺衍化而成的激素依賴型皮膚附屬物,也是哺乳動物重要的生殖器官。脊椎動物大部分器官的基本結(jié)構(gòu)至成年時保持相對恒定,但乳腺的結(jié)構(gòu)一直不斷改變[1-3]。青春期后受下丘腦-垂體-性腺的調(diào)控,乳腺形態(tài)呈周期性循環(huán)變化,最終經(jīng)過妊娠發(fā)育成熟泌乳,所以哺乳是雌性生殖生理的延續(xù)。毒物所致的乳汁數(shù)量或質(zhì)量下降會導(dǎo)致幼崽產(chǎn)生發(fā)育毒性。近年乳腺疾病發(fā)病率的增高已證實與內(nèi)分泌干擾物密切相關(guān)[4],如何評價這些干擾物對人類健康的影
[Abstract]:The positive breast is a hormone-dependent skin appendage derived from sweat gland, and it is also an important reproductive organ of mammals. The basic structure of most vertebrate organs remained relatively constant until adulthood, but the structure of breast kept changing [1 鈮,
本文編號:2486878
[Abstract]:The positive breast is a hormone-dependent skin appendage derived from sweat gland, and it is also an important reproductive organ of mammals. The basic structure of most vertebrate organs remained relatively constant until adulthood, but the structure of breast kept changing [1 鈮,
本文編號:2486878
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