發(fā)布時(shí)間：2019-05-11 06:00

【摘要】：目的建立HPLC法測(cè)定利巴韋林霧化吸入液中利巴韋林含量的方法,并對(duì)其體外沉積率進(jìn)行考察。方法采用SB-AQ C18色譜柱(250mm×4.6mm,5μm),流動(dòng)相為水,流速:1.0ml·min~(-1),檢測(cè)波長(zhǎng):207nm。采用新一代多級(jí)藥用撞擊器測(cè)定利巴韋林霧化吸入液的有效部位沉積率。結(jié)果在41.6~416μg·ml~(-1)范圍內(nèi),峰面積對(duì)質(zhì)量濃度有良好的線(xiàn)性關(guān)系,日內(nèi)精密度和日間精密度均2%(n=5);回收率在98%~102%;體外沉積率為68.51%。結(jié)論本含量測(cè)定方法準(zhǔn)確可靠、重復(fù)性好,該制劑的體外肺沉積率符合要求。
[Abstract]:Objective to establish a HPLC method for the determination of ribavirin in ribavirin atomized inhalation solution and to investigate its deposition rate in vitro. Methods SB-AQ C18 column (250mm 脳 4.6mm, 5 渭 m) was used, the mobile phase was water, the flow rate was 1.0ml 路min ~ (- 1), and the detection wavelength was 207nm. The deposition rate of effective parts of ribavirin atomized inhaler was determined by a new generation of multistage medicinal impactor. Results in the range of 41.6 渭 g 路ml ~ (- 1), the peak area had a good linear relationship with the mass concentration, the intra-day precision and inter-day precision were 2% (n 鈮，

本文編號(hào)：2474296