【摘要】：目的對甘草酸磷脂復(fù)合物自乳化制劑(self-emulsifying drug delivery system,SEDDS)進(jìn)行處方篩選及制備。方法用溶解性實(shí)驗(yàn),處方配伍實(shí)驗(yàn)和偽三元相圖等方法進(jìn)行甘草酸磷脂復(fù)合物SEDDS制備研究,優(yōu)選乳化劑,油相和助乳化劑;確定處方組分比例,考察處方自乳化效率。結(jié)果最佳甘草酸磷脂復(fù)合物SEDDS處方為Labrafil 1944 cs∶Cremophor EL35∶Transcutol HP=45∶40∶15,處方載藥量為27.3%;該處方能形成具有乳光透明乳液,粒度分布均勻。結(jié)論該方法可成功制備甘草酸磷脂復(fù)合物自乳化制劑。
[Abstract]:Objective to screen the prescription of glycyrrhizin complex self-emulsifying agent (self-emulsifying drug delivery system,SEDDS) and to prepare it. Methods the preparation of phosphatidyl glycyrrhizinate complex SEDDS was studied by means of solubility test, prescription compatibility test and pseudo-ternary phase diagram, the emulsifier, oil phase and co-emulsifier were optimized, the proportion of prescription components was determined, and the self-emulsifying efficiency of prescription was investigated. Results the optimal formulation of glycyrrhizin phospholipid complex SEDDS was Labrafil 1944 cs:Cremophor EL35:Transcutol HP=45:40:15, containing 27.3% of the drug, and the emulsion transparent emulsion could be formed with uniform particle size distribution. Conclusion the self-emulsifying preparation of glycyrrhizin complex can be successfully prepared by this method.
【作者單位】： 杭州市西溪醫(yī)院藥劑科;
【基金】：浙江省中醫(yī)藥管理局重點(diǎn)項(xiàng)目(2009ZA014)
【分類號】：R943

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