【摘要】：目的:為納米靶向載體研制提供參考。方法:以"腫瘤微環(huán)境""納米靶向載體""靶向治療""pH sensitive""Enzyme responsive""Redox responsive"等為關(guān)鍵詞,組合查詢2005-2016年在Pub Med、Elsevier、Springer Link、中國(guó)知網(wǎng)、萬(wàn)方、維普等數(shù)據(jù)庫(kù)中的相關(guān)文獻(xiàn),對(duì)腫瘤組織微環(huán)境的特點(diǎn)和腫瘤微環(huán)境響應(yīng)性納米載藥系統(tǒng)研究進(jìn)行綜述。結(jié)果與結(jié)論:共檢索到相關(guān)文獻(xiàn)235篇,其中有效文獻(xiàn)39篇。腫瘤組織微環(huán)境主要特點(diǎn)包括微酸性、酶代謝異常、細(xì)胞內(nèi)外存在還原性差異、存在影響腫瘤血管生成的因子和信號(hào)通路等�；谏鲜鎏攸c(diǎn),分別研究出基于腫瘤滯留效應(yīng)設(shè)計(jì)的納米載體、pH響應(yīng)型納米載體、還原響應(yīng)型納米載體、酶響應(yīng)型納米載體、溫度響應(yīng)型納米載體。與這些單響應(yīng)載體比較,腫瘤微環(huán)境多重刺激響應(yīng)型納米載體更能充分發(fā)揮不同腫瘤微環(huán)境響應(yīng)性物質(zhì)之間的特點(diǎn),對(duì)實(shí)現(xiàn)藥物的特異性遞送更有意義,這也將是今后的主要研究熱點(diǎn)。
[Abstract]:Objective: to provide reference for the development of nano-target carrier. Methods: using "tumor microenvironment", "nanometer target carrier", "targeted therapy", "pH sensitive", "Enzyme responsive", "Redox responsive" and so on as the key words, the authors combined the inquiry in Pub Med,Elsevier,Springer Link, from 2005 to 2016, Wanfang, China, China. The research on the characteristics of tumor microenvironment and the response of tumor microenvironment to nanopharmaceuticals was reviewed in this paper. Results & conclusion: a total of 235 related literatures were retrieved, of which 39 were valid. The main characteristics of tumor microenvironment include microacidity, abnormal enzyme metabolism, difference of reductivity in and out of cells, factors and signal pathways affecting tumor angiogenesis, etc. Based on the above characteristics, the nano-carriers designed based on tumor retention effect, pH responsive nano-carriers, reduction-responsive nano-carriers, enzyme responsive nano-carriers and temperature-responsive nanocarriers were studied respectively. Compared with these single response vectors, tumor microenvironment multi-stimuli responsive nanocarriers can give full play to the characteristics of different tumor microenvironment responsive substances, and have more significance for the specific delivery of drugs. This will also be the main research hotspot in the future.
【作者單位】： 黑龍江中醫(yī)藥大學(xué)藥學(xué)院;
【分類號(hào)】：R943

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本文編號(hào)：2408763