【摘要】：背景:研發(fā)藥物新劑型和制劑新技術已成為有望提高蛋白多肽利用率的熱點,尤其是近幾年的納米技術的研究進展更是促進了蛋白質藥物的臨床應用。目的:綜述蛋白口服納米給藥的研究現狀。方法:應用計算機檢索CNKI數據庫、SCI數據庫1996至2014年文獻,檢索中英文關鍵詞為"蛋白多肽,納米粒,口服制劑;protein,peptide drugs,nanoparticles,oral administration"。結果與結論:納米材料種類、納米粒粒徑、表面電荷及其表面修飾等對藥物的包封率、釋藥速度、納米粒在胃腸道內的穩(wěn)定性及透過腸黏膜的能力等方面有很大影響。納米粒可增加蛋白藥物的穩(wěn)定性,提高藥物的生物利用度;納米粒的靶向性可減少某些藥物的不良反應;納米粒的緩釋作用可以減少藥物的用量,增加藥物的體內循環(huán)時間。但納米技術目前仍有很多問題有待解決:制備過程中不可避免地會使一些蛋白藥物喪失活性;藥物的包封率及載藥量有待提高;蛋白突釋問題不能完全解決;納米粒目前大規(guī)模生產還很困難等。
[Abstract]:Background: the research and development of new drug formulations and new preparation technology has become a hot point in improving the utilization rate of protein peptides, especially in recent years, the research progress of nanotechnology has promoted the clinical application of protein drugs. Objective: to review the research status of oral nano-administration of protein. Methods: CNKI database and SCI database from 1996 to 2014 were searched by computer. The key words in Chinese and English were "protein polypeptide, nanoparticles, oral preparation; protein,peptide drugs,nanoparticles,oral administration". Results & conclusion: the kinds of nanomaterials, particle size, surface charge and surface modification have great influence on encapsulation efficiency, drug release rate, stability of gastrointestinal tract and ability of permeating intestinal mucosa. Nanoparticles can increase the stability of protein drugs and increase the bioavailability of drugs; the targeting of nanoparticles can reduce the adverse reactions of some drugs; the sustained release of nanoparticles can reduce the dosage of drugs and increase the time of drug circulation in vivo. However, there are still many problems to be solved in nanotechnology: some protein drugs will be inactivated inevitably in the preparation process, the encapsulation efficiency and drug loading should be improved, the problem of sudden release of protein can not be completely solved. At present, it is very difficult to produce nanocrystalline particles in large scale.
【作者單位】： 煙臺大學藥學院;
【分類號】：R944

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本文編號：2402205