【摘要】：目的:了解我院抗菌藥物致藥品不良反應(yīng)(ADR)發(fā)生的特點(diǎn)與規(guī)律,并探討有效的防治措施,為臨床安全、合理使用抗菌藥物提供參考。方法:收集我院2012-2014年上報(bào)國(guó)家ADR監(jiān)測(cè)中心的抗菌藥物致ADR報(bào)告111份,對(duì)抗菌藥物引發(fā)ADR所涉及的患者年齡與性別、給藥途徑、藥品種類(lèi)以及累及器官/系統(tǒng)和臨床表現(xiàn)等進(jìn)行統(tǒng)計(jì)、分析。結(jié)果:10歲患兒和60歲老年患者ADR發(fā)生率最高,分別占27.93%、25.23%;抗菌藥物靜脈給藥途徑ADR發(fā)生率最高,占84.68%;頭孢菌素類(lèi)藥物引發(fā)的ADR最多,占26.13%;抗菌藥物所致ADR主要累及皮膚及其附件損害,占44.92%。結(jié)論:臨床藥師可以此為切入點(diǎn)向臨床醫(yī)師、護(hù)士提供技術(shù)支持,防止ADR的重復(fù)發(fā)生。
[Abstract]:Objective: to investigate the characteristics and regularity of adverse drug reactions (ADR) caused by antimicrobial agents in our hospital, and to explore effective preventive and therapeutic measures to provide references for clinical safety and rational use of antimicrobial agents. Methods: one hundred and eleven cases of ADR caused by antimicrobial agents were collected and reported to the National ADR Surveillance Center in our hospital from 2012 to 2014. The age and sex of patients involved in ADR caused by antimicrobial agents and the route of administration were analyzed. Drug types, involved organs / systems and clinical manifestations were analyzed and analyzed. Results: the incidence of ADR in 10 years old children and 60 years old patients was the highest (27.93% 25.23), the incidence of ADR in intravenous administration of antibiotics was the highest (84.68%), the incidence of ADR induced by cephalosporins was the highest (26.13%). ADR caused by antimicrobial agents mainly involved skin and adnexal damage, accounting for 44.92%. Conclusion: clinical pharmacists can provide technical support to clinicians and nurses to prevent recurrence of ADR.
【作者單位】： 重慶醫(yī)科大學(xué)附屬永川醫(yī)院藥劑科;
【分類(lèi)號(hào)】：R95

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本文編號(hào)：2393246