【摘要】：以天然大豆卵磷脂為主要材料,膽固醇、近紅外量子點(diǎn)CdSeTe和超順磁性Fe_3O_4粒子為附加材料,DO_X為包封的藥物,制備了多功能復(fù)合載藥脂質(zhì)體。通過正交試驗(yàn)選取影響復(fù)合載藥脂質(zhì)體粒徑和包封率的5個(gè)因素,即磷脂濃度、藥脂比、超聲時(shí)間、水化溫度和Fe_3O_4量,每個(gè)因素選取4個(gè)水平進(jìn)行優(yōu)化實(shí)驗(yàn)。根據(jù)最優(yōu)條件,采用薄膜分散發(fā)制備了多功能復(fù)合載藥脂質(zhì)體并對(duì)其粒徑、磁性和熒光性質(zhì)進(jìn)行了測(cè)定。結(jié)果表明多功能復(fù)合載藥脂質(zhì)體粒徑大約200nm、近似球形,且具有良好的近紅外熒光性能和磁響應(yīng)性能。
[Abstract]:Using natural soybean lecithin as main material, cholesterol, near-infrared quantum dot CdSeTe and superparamagnetic Fe_3O_4 particles as additional materials, and DO_X as encapsulated drug, the multifunctional compound drug-loaded liposomes were prepared. Five factors affecting the particle size and entrapment efficiency of the composite liposome were selected by orthogonal test, namely, the concentration of phospholipid, the ratio of liposomes to liposomes, ultrasonic time, hydration temperature and the amount of Fe_3O_4, and each factor was selected at 4 levels to optimize the experiment. According to the optimum conditions, the multifunctional composite liposomes were prepared by dispersion of films and their particle size, magnetic properties and fluorescence properties were determined. The results show that the multifunctional composite liposomes are about 200 nm in diameter, nearly spherical, and have good near infrared fluorescence and magnetic response.
【作者單位】： 四川大學(xué)化工學(xué)院;
【基金】：國(guó)家自然科學(xué)基金項(xiàng)目(2097072)
【分類號(hào)】：R943

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