內(nèi)源性外泌體作為藥物遞釋系統(tǒng)的研究進展
發(fā)布時間:2018-12-14 11:21
【摘要】:外泌體是一種活細胞分泌的直徑為40~100nm的囊狀小泡,是細胞間信息傳遞、物質(zhì)交換的重要媒介。作為天然內(nèi)源性的物質(zhì)轉(zhuǎn)運載體,采用外泌體負載藥物具有毒性低、無免疫原性、滲透性好等優(yōu)勢,目前,外泌體已成功負載小分子化學藥物、基因藥物用于治療腫瘤及阿爾茨海默癥等疾病。文章將基于外泌體的發(fā)展情況就外泌體在藥物遞送系統(tǒng)中的應(yīng)用進行詳細的介紹分析。
[Abstract]:Exocrine body is a vesicular vesicle with diameter of 40~100nm secreted by living cells. It is an important medium for information transmission and material exchange between cells. As a natural endogenous material transport carrier, the use of exocrine loaded drugs has the advantages of low toxicity, no immunogenicity, good permeability and so on. At present, exocrine has successfully loaded small molecular chemical drugs. Genetic drugs are used to treat diseases such as cancer and Alzheimer's disease. Based on the development of exocrine, the application of exocrine in drug delivery system is introduced and analyzed in detail.
【作者單位】: 廣東藥科大學藥劑系;
【基金】:廣東省自然科學基金(2014A030310362) 廣州市科技計劃項目(201508010036) 廣州市產(chǎn)學研協(xié)同創(chuàng)新重大專項(201605131249066)
【分類號】:R943
本文編號:2378530
[Abstract]:Exocrine body is a vesicular vesicle with diameter of 40~100nm secreted by living cells. It is an important medium for information transmission and material exchange between cells. As a natural endogenous material transport carrier, the use of exocrine loaded drugs has the advantages of low toxicity, no immunogenicity, good permeability and so on. At present, exocrine has successfully loaded small molecular chemical drugs. Genetic drugs are used to treat diseases such as cancer and Alzheimer's disease. Based on the development of exocrine, the application of exocrine in drug delivery system is introduced and analyzed in detail.
【作者單位】: 廣東藥科大學藥劑系;
【基金】:廣東省自然科學基金(2014A030310362) 廣州市科技計劃項目(201508010036) 廣州市產(chǎn)學研協(xié)同創(chuàng)新重大專項(201605131249066)
【分類號】:R943
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