【摘要】：目的建立氣相質(zhì)譜方法的同時測定甲磺酸培氟沙星中甲磺酸甲酯(MMS)、甲磺酸乙酯(EMS)和甲磺酸異丙酯(IMS)含量。方法經(jīng)碘代試劑的柱前衍生化,將3種甲磺酸酯衍生成碘甲烷,碘乙烷和碘代異丙烷,利用DB-Wax石英毛細管柱(30m×0.25mm,0.25μm)分離,質(zhì)譜檢測器檢測。結(jié)果 MMS、EMS和IMS分別在34~549、31~499和26~411ng/m L具有良好的線性(r≥0.9999),平均回收率分別為101.8%、102.9%和100.6%,定量限≤2.6ng/m L。結(jié)論該方法可用于甲磺酸培氟沙星中甲磺酸酯類雜質(zhì)的分離分析,該方法簡便、準確且快速。
[Abstract]:Objective to establish a method for simultaneous determination of methyl methanesulfonate (MMS),) ethyl methanesulfonate (EMS) and isopropyl mesosulfonate (IMS) in pefloxacin mesylate by gas phase mass spectrometry. Methods three kinds of methanesulfonate were derived into methane iodide, ethane and isopropane by pre-column derivatization of iodide reagent, and separated by DB-Wax quartz capillary column (30m 脳 0.25mm ~ 0.25 渭 m) and detected by mass spectrometry. Results MMS,EMS and IMS had a good linearity (r 鈮，

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