發(fā)布時間：2018-11-20 08:22

【摘要】：四氫嘧啶及衍生物(Ectoines,Ects)是嗜鹽或耐鹽細菌胞內(nèi)合成的一類能夠抵抗外界高鹽脅迫的有機相容溶質(zhì)(Compatible solute),主要包括四氫嘧啶(Ectoine)與羥基化四氫嘧啶(5-hydroxyectoine,5-HE)。在高溫、干旱、高pH值、高壓和高鹽等極端環(huán)境條件下,Ects不僅能夠平衡細胞的滲透壓,而且對蛋白質(zhì)、DNA、細胞膜以及整個細胞提供抗逆協(xié)助作用。本文綜述了Ects對生物大分子和細胞的保護與穩(wěn)定作用,以及在臨床疾病治療應(yīng)用方面的輔助作用,并討論與展望了Ects在生物醫(yī)藥制劑和生物保健開發(fā)等方面的應(yīng)用前景。
[Abstract]:Tetrahydropyrimidine and its derivatives (Ectoines,Ects) are a kind of organo-compatible solute (Compatible solute), which is synthesized by halophilic or halophilic bacteria and can resist high salt stress. It mainly includes tetrahydropyrimidine (Ectoine) and hydroxylated tetrahydropyrimidine (5-hydroxyectoine). 5-HE) Under extreme conditions such as high temperature, drought, high pH value, high pressure and high salt, Ects can not only balance the osmotic pressure of cells, but also provide stress resistance to protein, DNA, cell membrane and the whole cell. This paper reviews the protective and stable effects of Ects on biomolecules and cells, and its auxiliary role in the treatment of clinical diseases, and discusses and prospects the application prospects of Ects in biomedical preparations and biological health care development.
【作者單位】： 青海大學(xué)醫(yī)學(xué)院基礎(chǔ)醫(yī)學(xué)研究中心;
【基金】：國家自然科學(xué)基金(31560039) 青海省科技計劃(2013Z725;2015ZJ929Q)
【分類號】：R915
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本文編號：2344382